Fanciullacci M, Pietrini U, Geppetti P, Nicolodi M, Curradi C, Sicuteri F
Institute of Internal Medicine and Clinical Pharmacology, University of Florence, Italy.
Cephalalgia. 1988 Mar;8(1):49-53. doi: 10.1046/j.1468-2982.1988.0801049.x.
Substance P-like immunoreactivity (SP-LI) was measured by radioimmunoassay in iris, choroid, and retina obtained from men after death. Although present in different amounts, SP-LI, eluting as authentic SP or SP sulfoxide in the high-performance liquid chromatography system, was found in the three ocular structures. The retina contained higher concentrations of SP-LI than the iris and choroid. The possible functional involvement of iris SP was studied in 22 episodic cluster headache (CH) patients by using the anticholinesterase agent echothiophate iodide (EI), which also induces an atropine-resistant miosis, putatively due to release of SP from trigeminal sensory neurons. In CH patients EI eye drops instilled into both eyes provoked a prolonged miosis with a more marked response in the pupil of the symptomatic eye. It is proposed that the hyperfunction of SP-containing neurons may coexist with the previously documented sympathetic hypofunction in the innervation of the symptomatic pupil of CH.
采用放射免疫分析法对死后男性的虹膜、脉络膜和视网膜进行P物质样免疫反应性（SP-LI）测定。尽管含量不同，但在高效液相色谱系统中以 authentic SP或SP亚砜形式洗脱的SP-LI在这三种眼部结构中均有发现。视网膜中SP-LI的浓度高于虹膜和脉络膜。通过使用抗胆碱酯酶药物碘化依可碘酯（EI），对22例发作性丛集性头痛（CH）患者虹膜SP的可能功能参与情况进行了研究，碘化依可碘酯也可诱导阿托品抵抗性瞳孔缩小，推测这是由于三叉神经感觉神经元释放SP所致。在CH患者中，双眼滴入EI眼药水会引发长时间的瞳孔缩小，患侧眼瞳孔的反应更为明显。有人提出，在CH患侧瞳孔的神经支配中，含SP神经元的功能亢进可能与先前记录的交感神经功能减退并存。
