Sicuteri F, Fanciullacci M, Geppetti P, Renzi D, Caleri D, Spillantini M G
Cephalalgia. 1985 Sep;5(3):143-9. doi: 10.1046/j.1468-2982.1985.0503143.x.
Substance P (SP), present in sensory afferent neurons, seems to process nociceptive information in the trigeminal system. SP, released from peripheral trigeminal endings, causes typical cluster headache (CH) signs, e.g. vasodilatation, conjunctival and nasal edema and miosis. Opiates and somatostatin (SRIF), both active in relieving CH attack, inhibit SP release from the central and peripheral trigeminal system. In the present study, plasma and cerebrospinal fluid (CSF), SP-like immunoreactivity (SPLI) and enkephalinase activity (EKA), and plasma SRIF-like immunoreactivity (SRIFLI) have been evaluated during spontaneous and histamine induced attacks in the cluster phase. During the histamine provoked attacks, CSF SPLI and plasma SRIFLI and EKA were unchanged, while plasma SPLI decreased significantly. During spontaneously occurring attacks, plasma SRIFLI was found to be unmodified and a significant lowering of SPLI was detected when compared with controls. Moreover, both during and between attacks in the cluster phase, plasma EKA was increased in comparison with the values in controls. It remains to be seen whether variations of plasma SPLI and EKA levels play a role in the CH mechanism.
存在于感觉传入神经元中的P物质（SP）似乎在三叉神经系统中处理伤害性信息。从外周三叉神经末梢释放的SP会引发典型的丛集性头痛（CH）症状，如血管扩张、结膜和鼻黏膜水肿以及瞳孔缩小。阿片类药物和生长抑素（SRIF）都能有效缓解CH发作，它们可抑制SP从中央和外周三叉神经系统释放。在本研究中，对丛集期自发发作和组胺诱发发作期间的血浆和脑脊液（CSF）中的P物质样免疫反应性（SPLI）、脑啡肽酶活性（EKA）以及血浆生长抑素样免疫反应性（SRIFLI）进行了评估。在组胺诱发发作期间，脑脊液SPLI、血浆SRIFLI和EKA未发生变化，而血浆SPLI显著降低。在自发发作期间，发现血浆SRIFLI未改变，与对照组相比，SPLI显著降低。此外，在丛集期发作期间及发作间期，与对照组相比，血浆EKA均升高。血浆SPLI和EKA水平的变化是否在CH机制中起作用仍有待观察。
