Nicolodi M, Del Bianco E
Institute of Internal Medicine, Headache Center, Firenze, Italy.
Cephalalgia. 1990 Feb;10(1):39-50. doi: 10.1046/j.1468-2982.1990.1001039.x.
Substance P, calcitonin gene-related peptide and vasoactive intestinal polypeptide-like immunoreactivities have been evaluated in the saliva of 15 subjects suffering from migraine without aura and 16 control subjects. All three peptides were also measured in the symptomatic/non-symptomatic side saliva sampled from 10 cluster headache sufferers during the cluster period, 5 cluster headache sufferers out of the cluster period, as well as in the right and left side saliva of 18 control subjects. The most interesting result gives a clear difference in common migraine and cluster headache salivary vasoactive intestinal polypeptide-like immunoreactivity contents. In fact, these are enhanced during cluster headache attack and decreased during migraine attack when compared with the interictal period vasoactive intestinal polypeptide-like immunoreactivity levels. Another remarkable finding concerns the significant increase of substance P-like immunoreactivity and calcitonin gene-related peptide-like immunoreactivity levels, from basal values, in the saliva sampled during both migraine and cluster headache attacks. Control subjects showed a calcitonin gene-related peptide-like immunoreactivity and substance P-like immunoreactivity salivary contents significantly higher than migraine sufferers' saliva sampled in basal conditions. Conversely, calcitonin gene-related peptide-like immunoreactivities levels in controls were lower than in cluster headache sufferers' saliva obtained during intervals. Finally, during cluster headache attacks the enhancement of substance P-like immunoreactivity and vasoactive intestinal polypeptide-like immunoreactivity salivary contents interest the non-symptomatic side, whereas the symptomatic side salivary substance P-like immunoreactivity and vasoactive intestinal polypeptide-like immunoreactivity contents remain unchanged. These findings do not allow any final conclusion. However, this biochemical evaluation indicates relevant changes of the salivary neuropeptides in diseases, such as migraine and cluster headache, in which pain transmission is surely involved.
对15名无先兆偏头痛患者和16名对照者的唾液中P物质、降钙素基因相关肽和血管活性肠肽样免疫反应性进行了评估。还对10名丛集性头痛患者在丛集期、5名丛集性头痛患者在丛集期之外以及18名对照者的左右两侧唾液中进行了这三种肽的检测。最有趣的结果是，普通偏头痛和丛集性头痛患者唾液中血管活性肠肽样免疫反应性含量存在明显差异。事实上，与发作间期血管活性肠肽样免疫反应性水平相比，这些含量在丛集性头痛发作时升高，在偏头痛发作时降低。另一个显著发现是，在偏头痛和丛集性头痛发作期间采集的唾液中，P物质样免疫反应性和降钙素基因相关肽样免疫反应性水平较基础值显著升高。对照者唾液中降钙素基因相关肽样免疫反应性和P物质样免疫反应性含量显著高于基础状态下偏头痛患者的唾液。相反，对照者的降钙素基因相关肽样免疫反应性水平低于丛集性头痛患者发作间期的唾液。最后，在丛集性头痛发作期间，P物质样免疫反应性和血管活性肠肽样免疫反应性唾液含量的升高出现在无症状侧，而有症状侧唾液中P物质样免疫反应性和血管活性肠肽样免疫反应性含量保持不变。这些发现无法得出任何最终结论。然而，这种生化评估表明，在偏头痛和丛集性头痛等肯定涉及疼痛传递的疾病中，唾液神经肽发生了相关变化。
