Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Front Public Health. 2022 Aug 15;10:882686. doi: 10.3389/fpubh.2022.882686. eCollection 2022.
To evaluate the correlation of nesfatin-1, GSH and SOD levels with β-cell insulin secretion and their influence on insulin secretion in the development of type 2 diabetes mellitus (T2DM).
75 patients with T2DM, 67 with prediabetes and 37 heathy participants were recruited in this study. Serum levels of nesfatin-1, GSH and SOD were quantified and statistically analyzed.
The levels of nesfatin-1, GSH and SOD in T2DM were significantly decreased ( < 0.001) compared to either in prediabetes or in healthy control, and significant reduction of these biomarkers was also observed in prediabetes when compared to the control ( < 0.001). Circulating nesfatin-1, GSH and SOD were not only strongly correlated with β-cell insulin secretion, but also exerted remarkable influence on the secretion.
Serum nesfatin-1, GSH and SOD are important factors involving insulin secretion in the development of T2DM, which may help provide new ideas for forthcoming investigations on the roles of these factors in pathogenesis of T2DM, as well as for active prediction and prevention of prediabetes before it develops into overt T2DM.
评估 nesfatin-1、GSH 和 SOD 水平与β细胞胰岛素分泌的相关性及其对 2 型糖尿病（T2DM）发生过程中胰岛素分泌的影响。
本研究纳入了 75 例 T2DM 患者、67 例糖尿病前期患者和 37 名健康对照者。定量检测并统计分析了血清 nesfatin-1、GSH 和 SOD 水平。
与健康对照组相比，T2DM 患者的 nesfatin-1、GSH 和 SOD 水平显著降低（<0.001），而与健康对照组相比，糖尿病前期患者的这些生物标志物水平也显著降低（<0.001）。循环 nesfatin-1、GSH 和 SOD 不仅与β细胞胰岛素分泌密切相关，而且对其分泌也有显著影响。
血清 nesfatin-1、GSH 和 SOD 是 T2DM 发展过程中涉及胰岛素分泌的重要因素，这可能有助于为这些因素在 T2DM 发病机制中的作用以及在糖尿病前期发展为显性 T2DM 之前进行积极预测和预防提供新的思路。
