铱催化的对映选择性烯丙基-烯烃偶联反应。
Iridium-catalyzed enantioselective allyl-alkene coupling.
机构信息
Eidgenössische Technische Hochschule Zürich , HCI H335, 8093 Zürich, Switzerland.
出版信息
J Am Chem Soc. 2014 Feb 26;136(8):3006-9. doi: 10.1021/ja412962w. Epub 2014 Feb 12.
PMID:24521052
Abstract
The direct Ir-catalyzed cross-coupling between branched, racemic allylic alcohols and simple olefins is described. This transformation is catalyzed by an Ir-(P,olefin) complex and proceeds with high site selectivity and excellent enantioselectivity. The method allows rapid access to various 1,5-dienes or trienes and was used in the catalytic asymmetric synthesis of the γ-secretase modulator JNJ-40418677.
摘要
本文描述了手性支链烯丙醇与简单烯烃的直接 Ir 催化交叉偶联反应。该转化由 Ir-(P,olefin) 配合物催化，具有高的位点选择性和优异的对映选择性。该方法可快速得到各种 1,5-二烯或三烯，并用于 γ-分泌酶调节剂 JNJ-40418677 的催化不对称合成。
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