对映选择性 Ir 催化的外消旋烯丙醇与丙二酸酯的烯丙基烷基化反应。
Enantioselective Ir-Catalyzed Allylic Alkylation of Racemic Allylic Alcohols with Malonates.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
出版信息
Org Lett. 2019 Feb 1;21(3):840-843. doi: 10.1021/acs.orglett.8b04143. Epub 2019 Jan 23.
Ir-catalyzed enantioselective allylic alkylation of branched racemic allylic alcohols with malonates is described. Enabled by Carreira's chiral Ir/(P, olefin) complex, the method described allows allylic substitution with various aromatic alcohols and malonates with excellent enantioselectivity. The malonates could be used directly as efficient nucleophiles without the need of preactivation.
手性铱催化的支链外消旋烯丙醇与丙二酸酯的对映选择性烯丙基烷基化反应被描述。在 Carreira 的手性 Ir/(P,烯烃)配合物的作用下，该方法允许各种芳醇和丙二酸酯与烯丙基进行取代反应，具有优异的对映选择性。丙二酸酯可以直接用作有效的亲核试剂，而无需预先活化。
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