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模拟隐形眼镜上泪膜的蒸发。

Modelling the evaporation of a tear film over a contact lens.

作者信息

Talbott Kevin, Xu Amber, Anderson Daniel M, Seshaiyer Padmanabhan

机构信息

Department of Mathematical Sciences, George Mason University, Fairfax, VA 22030, USA.

Electrical and Computer Engineering, Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

出版信息

Math Med Biol. 2015 Jun;32(2):209-38. doi: 10.1093/imammb/dqu001. Epub 2014 Feb 11.

Abstract

A contact lens (CL) separates the tear film into a pre-lens tear film (PrLTF), the fluid layer between the CL and the outside environment, and a post-lens tear film (PoLTF), the fluid layer between the CL and the cornea. We examine a model for evaporation of a PrLTF on a modern permeable CL allowing fluid transfer between the PrLTF and the PoLTF. Evaporation depletes the PrLTF, and continued evaporation causes depletion of the PoLTF via fluid loss through the CL. Governing equations include Navier-Stokes, heat and Darcy's equations for the fluid flow and heat transfer in the PrLTF and porous layer. The PoLTF is modelled by a fixed pressure condition on the posterior surface of the CL. The original model is simplified using lubrication theory for the PrLTF and CL applied to a sagittal plane through the eye. We obtain a partial differential equation (PDE) for the PrLTF thickness that is first-order in time and fourth-order in space. This model incorporates evaporation, conjoining pressure effects in the PrLTF, capillarity and heat transfer. For a planar film, we find that this PDE can be reduced to an ordinary differential equation (ODE) that can be solved analytically or numerically. This reduced model allows for interpretation of the various system parameters and captures most of the basic physics contained in the model. Comparisons of ODE and PDE models, including estimates for the loss of fluid through the lens due to evaporation, are given.

摘要

隐形眼镜(CL)将泪膜分为镜片前泪膜(PrLTF),即CL与外部环境之间的流体层,以及镜片后泪膜(PoLTF),即CL与角膜之间的流体层。我们研究了一种现代可渗透CL上PrLTF蒸发的模型,该模型允许PrLTF与PoLTF之间进行流体传输。蒸发会消耗PrLTF,持续蒸发会通过CL的流体损失导致PoLTF耗尽。控制方程包括Navier-Stokes方程、热方程和Darcy方程,用于PrLTF和多孔层中的流体流动和热传递。PoLTF通过CL后表面上的固定压力条件进行建模。原始模型通过将适用于PrLTF和CL的润滑理论应用于穿过眼睛的矢状面进行简化。我们得到了一个关于PrLTF厚度的偏微分方程(PDE),它在时间上是一阶的,在空间上是四阶的。该模型包含了蒸发、PrLTF中的联合压力效应、毛细作用和热传递。对于平面薄膜,我们发现这个PDE可以简化为一个常微分方程(ODE),可以通过解析或数值方法求解。这个简化模型允许解释各种系统参数,并捕捉模型中包含的大部分基本物理现象。给出了ODE和PDE模型的比较,包括由于蒸发导致的通过镜片的流体损失估计。

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