McLaughlin Paula M, Wright Matthew J, Larocca Michael, Nguyen Peter T, Teng Edmond, Apostolova Liana G, Ringman John M, Zhou Yan, Cummings Jeffrey L, Woo Ellen
1 Department of Neurology, University of California, Los Angeles, Los Angeles, California.
2 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.
J Int Neuropsychol Soc. 2014 Apr;20(4):402-12. doi: 10.1017/S135561771400006X. Epub 2014 Feb 13.
Impairments in learning and recall have been well established in amnestic mild cognitive impairment (aMCI). However, a relative dearth of studies has examined the profiles of memory strategy use in persons with aMCI relative to those with Alzheimer's disease (AD). Participants with aMCI, nonamnestic MCI, AD, and healthy older adults were administered the California Verbal Learning Test-II (CVLT-II). Measures of semantic clustering and recall were obtained across learning and delayed recall trials. In addition, we investigated whether deficits in semantic clustering were related to progression from healthy aging to aMCI and from aMCI to AD. The aMCI group displayed similar semantic clustering performance as the AD participants, whereas the AD group showed greater impairments on recall relative to the aMCI participants. Control participants who progressed to aMCI showed reduced semantic clustering at the short delay at baseline compared to individuals who remained diagnostically stable across follow-up visits. These findings show that the ability to engage in an effective memory strategy is compromised in aMCI, before AD has developed, suggesting that disruptions in semantic networks are an early marker of the disease. (JINS, 2014, 20, 1-11).
遗忘型轻度认知障碍（aMCI）患者在学习和记忆方面的损害已得到充分证实。然而，相对于阿尔茨海默病（AD）患者，对aMCI患者记忆策略使用情况的研究相对较少。对aMCI、非遗忘型MCI、AD患者以及健康老年人进行了加利福尼亚言语学习测验第二版（CVLT-II）测试。在学习和延迟回忆试验中获取语义聚类和回忆的测量数据。此外，我们还研究了语义聚类缺陷是否与从健康衰老到aMCI以及从aMCI到AD的进展有关。aMCI组的语义聚类表现与AD参与者相似，而AD组在回忆方面相对于aMCI参与者表现出更大的损害。与在随访中诊断保持稳定的个体相比，进展为aMCI的对照参与者在基线短期延迟时语义聚类减少。这些发现表明，在AD发生之前，aMCI患者有效运用记忆策略的能力就已受损，这表明语义网络的破坏是该疾病的早期标志。（《神经心理学杂志》，2014年，第20卷，第1 - 11页）
