Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland; Department of Dermatology, Mie University Graduate School of Medicine, Mie, Japan.
Laboratoire Central d'Hématologie, Groupe Hospitalier Pitié-Salpêtrière (Paris), and LBPA, CNRS UMR 8113, Ecole Normale Supérieure de Cachan, Cachan, France.
J Am Acad Dermatol. 2014 Apr;70(4):683-690.e1. doi: 10.1016/j.jaad.2013.12.002. Epub 2014 Feb 9.
Psoriasis is a chronic inflammatory skin disease and various stress factors mediate inflammation. Heat shock protein (HSP) 90 plays an important role in cell survival; cytokine signaling, such as interleukin-17 receptor signaling; and immune responses.
We sought to elucidate protein expression and distribution of HSP90 in psoriasis.
HSP90 expression and its cellular source were analyzed on normal-appearing, nonlesional, lesional, and ustekinumab-treated psoriatic skin using immunohistochemistry and double immunofluorescence.
HSP90α, the inducible isoform of HSP90, was significantly up-regulated in epidermal keratinocytes and mast cells of lesional skin and down-regulated after ustekinumab therapy.
There was a limited sample size.
HSP90 from keratinocytes and mast cells is a key regulator of psoriatic inflammation and HSP90 inhibitors may represent a novel therapeutic approach to the disease.
银屑病是一种慢性炎症性皮肤病，各种应激因素介导炎症反应。热休克蛋白（HSP）90 在细胞存活、细胞因子信号转导（如白细胞介素-17 受体信号转导）和免疫反应中起着重要作用。
我们旨在阐明 HSP90 在银屑病中的蛋白表达和分布。
采用免疫组织化学和双重免疫荧光法分析正常、非皮损、皮损和乌司奴单抗治疗的银屑病皮肤中 HSP90 的表达及其细胞来源。
HSP90α，HSP90 的诱导型同工酶，在皮损表皮角质形成细胞和肥大细胞中显著上调，乌司奴单抗治疗后下调。
样本量有限。
角质形成细胞和肥大细胞中的 HSP90 是银屑病炎症的关键调节因子，HSP90 抑制剂可能代表该疾病的一种新的治疗方法。
