Modern Research Center for Traditional Chinese Medicine, The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.
Int J Mol Sci. 2023 Sep 21;24(18):14390. doi: 10.3390/ijms241814390.
Psoriasis is an incurable skin disease that develops in about two-thirds of patients before the age of 40 and requires lifelong treatment; its pathological mechanisms have not been fully elucidated. The core pathological process of psoriasis is epidermal thickening caused by the excessive proliferation of epidermal keratinocytes, which is similar to the key feature of cancer; the malignant proliferation of cancer cells causes tumor enlargement, suggesting that there is a certain degree of commonality between psoriasis and cancer. This article reviews the pathological mechanisms that are common to psoriasis and cancer, including the interaction between cell proliferation and an abnormal immune microenvironment, metabolic reprogramming, and epigenetic reprogramming. In addition, there are common therapeutic agents and drug targets between psoriasis and cancer. Thus, psoriasis and cancer share a common pathological mechanisms-drug targets-therapeutic agents framework. On this basis, it is proposed that investigating psoriasis from a cancer perspective is beneficial to enriching the research strategies related to psoriasis.
银屑病是一种无法治愈的皮肤病，大约有三分之二的患者在 40 岁之前发病，需要终身治疗；其发病机制尚未完全阐明。银屑病的核心病理过程是表皮角质形成细胞过度增殖导致的表皮增厚，这与癌症的关键特征相似；癌细胞的恶性增殖导致肿瘤增大，提示银屑病和癌症之间存在一定程度的共性。本文综述了银屑病和癌症共有的病理机制，包括细胞增殖与异常免疫微环境的相互作用、代谢重编程和表观遗传重编程。此外，银屑病和癌症之间还存在共同的治疗药物和药物靶点。因此，银屑病和癌症共享一个共同的病理机制-药物靶点-治疗药物框架。在此基础上，提出从癌症角度研究银屑病有助于丰富与银屑病相关的研究策略。
