Bunyavanich Supinda, Rifas-Shiman Sheryl L, Platts-Mills Thomas A, Workman Lisa, Sordillo Joanne E, Camargo Carlos A, Gillman Matthew W, Gold Diane R, Litonjua Augusto A
Division of Pediatric Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Mass; Harvard Medical School, Boston, Mass.
J Allergy Clin Immunol. 2014 May;133(5):1373-82. doi: 10.1016/j.jaci.2013.11.040. Epub 2014 Feb 9.
Maternal diet during pregnancy may affect childhood allergy and asthma.
We sought to examine the associations between maternal intake of common childhood food allergens during early pregnancy and childhood allergy and asthma.
We studied 1277 mother-child pairs from a US prebirth cohort unselected for any disease. Using food frequency questionnaires administered during the first and second trimesters, we assessed maternal intake of common childhood food allergens during pregnancy. In mid-childhood (mean age, 7.9 years), we assessed food allergy, asthma, allergic rhinitis, and atopic dermatitis by questionnaire and serum-specific IgE levels. We examined the associations between maternal diet during pregnancy and childhood allergy and asthma. We also examined the cross-sectional associations between specific food allergies, asthma, and atopic conditions in mid-childhood.
Food allergy was common (5.6%) in mid-childhood, as was sensitization to at least 1 food allergen (28.0%). Higher maternal peanut intake (each additional z score) during the first trimester was associated with 47% reduced odds of peanut allergic reaction (odds ratio [OR], 0.53; 95% CI, 0.30-0.94). Higher milk intake during the first trimester was associated with reduced asthma (OR, 0.83; 95% CI, 0.69-0.99) and allergic rhinitis (OR, 0.85; 95% CI, 0.74-0.97). Higher maternal wheat intake during the second trimester was associated with reduced atopic dermatitis (OR, 0.64; 95% CI, 0.46-0.90). Peanut, wheat, and soy allergy were each cross-sectionally associated with increased childhood asthma, atopic dermatitis, and allergic rhinitis (ORs, 3.6 to 8.1).
Higher maternal intake of peanut, milk, and wheat during early pregnancy was associated with reduced odds of mid-childhood allergy and asthma.
孕期母亲的饮食可能会影响儿童过敏和哮喘。
我们试图研究孕早期母亲摄入常见儿童食物过敏原与儿童过敏和哮喘之间的关联。
我们对来自美国一个未因任何疾病而被筛选的产前队列的1277对母婴进行了研究。通过在孕早期和孕中期使用食物频率问卷，我们评估了孕期母亲对常见儿童食物过敏原的摄入量。在儿童中期（平均年龄7.9岁），我们通过问卷和血清特异性IgE水平评估了食物过敏、哮喘、过敏性鼻炎和特应性皮炎。我们研究了孕期母亲饮食与儿童过敏和哮喘之间的关联。我们还研究了儿童中期特定食物过敏、哮喘和特应性疾病之间的横断面关联。
食物过敏在儿童中期很常见（5.6%），对至少一种食物过敏原致敏的情况也很常见（28.0%）。孕早期母亲花生摄入量每增加一个z分数，花生过敏反应的几率降低47%（比值比[OR]，0.53；95%可信区间，0.30 - 0.94）。孕早期牛奶摄入量较高与哮喘几率降低（OR，0.83；95%可信区间，0.69 - 0.99）和过敏性鼻炎几率降低（OR，0.85；95%可信区间，0.74 - 0.97）相关。孕中期母亲小麦摄入量较高与特应性皮炎几率降低（OR，0.64；95%可信区间，0.46 - 0.90）相关。花生、小麦和大豆过敏分别与儿童哮喘、特应性皮炎和过敏性鼻炎的增加存在横断面关联（OR为3.6至8.1）。
孕早期母亲较高的花生、牛奶和小麦摄入量与儿童中期过敏和哮喘几率降低相关。
