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在水中通过 2-氨基苯甲腈和芳香醛基合成 2-芳基-2,3-二氢喹唑啉-4(1H)-酮。

Base mediated synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzonitriles and aromatic aldehydes in water.

机构信息

Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province, People's Republic of China.

出版信息

Org Biomol Chem. 2014 Mar 28;12(12):1865-70. doi: 10.1039/c3ob42434k. Epub 2014 Feb 12.

DOI:10.1039/c3ob42434k
PMID:24522449
Abstract

An environmentally friendly and mild procedure to obtain 2,3-dihydroquinazolin-4(1H)-ones from 2-aminobenzonitriles and aromatic aldehydes has been developed. The reactions took place in water with inorganic base (K3PO4) as the only promoter. Various desired products have been prepared in moderate to good yields under identical conditions. Further transformation of dihydroquinazolinones to quinazolinones was carried out as well with TBHP as the oxidant.

摘要

一种从 2-氨基苯甲腈和芳香醛出发制备 2,3-二氢喹唑啉-4(1H)-酮的绿色温和方法已经开发出来。该反应在水中进行，以无机碱（K3PO4）作为唯一的促进剂。在相同条件下，各种目标产物都以中等至良好的收率制备得到。进一步使用 TBHP 作为氧化剂，将二氢喹唑啉酮转化为喹唑啉酮。

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