WuXi AppTec (Shanghai) Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131 (China).
Chemistry. 2014 Mar 10;20(11):3162-8. doi: 10.1002/chem.201303809. Epub 2014 Feb 12.
We report herein a general catalytic method for Csp(2)-Csp(3) bond formation through C-F activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with β-hydrogen atoms. A variety of fluorine substitution patterns and functional groups can be readily incorporated. Sequential reactions involving different precatalysts and coupling partners permit the synthesis of densely functionalized fluorinated building blocks.
我们在此报告了一种通过 C-F 活化形成 Csp(2)-Csp(3)键的通用催化方法。该过程使用廉价的镍配合物与二有机锌或卤化烷基锌试剂（包括带有β-氢原子的试剂）一起使用。各种氟取代模式和官能团可以很容易地引入。涉及不同前催化剂和偶联伙伴的顺序反应允许合成具有高度官能化的氟化构建块。
