Watmough D J, Moran C, Watmough J A
Department of Biomedical Physics and Bio-Engineering, Medical School, University of Aberdeen, Foresterhill, UK.
J Biomed Eng. 1988 Apr;10(2):119-23. doi: 10.1016/0141-5425(88)90085-4.
X-ray mammography is the gold standard for diagnosis of lesions within the female breast. It is also recognized as the technique of choice for breast cancer screening in women over 50-years-old. Notwithstanding these important roles it has shortcomings in terms of limited sensitivity and specificity, especially in younger women. This paper describes the concept of a combined optical density and Doppler ultrasound method proposed initially as a supplement to mammography. A specially devised tissue compressor is also described. Results obtained using test phantoms and initial clinical studies are presented. Neovascularization at the advancing front of neoplastic lesions is believed to underlie detection of lesions by both telediaphanography and Doppler ultrasound.
X线乳房造影术是诊断女性乳腺病变的金标准。它也被公认为是50岁以上女性乳腺癌筛查的首选技术。尽管它有这些重要作用，但在敏感性和特异性方面存在局限性，尤其是在年轻女性中。本文描述了一种最初作为乳房造影术补充手段提出的光密度和多普勒超声联合方法的概念。还介绍了一种专门设计的组织压缩器。展示了使用测试体模获得的结果以及初步临床研究结果。肿瘤病变前沿的新生血管形成被认为是通过远距透照术和多普勒超声检测病变的基础。
