XRCC3基因C722T多态性与喉癌的相关性：一项荟萃分析。
Association of C722T polymorphism in XRCC3 gene with larynx cancer: a meta-analysis.
作者信息
Li Dong, You Hui-Hua, Jia Yuan-Jing, Guo Jian-Dong, Du Huan-Le
机构信息
Department of Otolaryngology-Head and Neck Surgery, Center Hospital of Jinhua City, Zhejiang, 321000, People's Republic of China.
出版信息
Tumour Biol. 2014 Jun;35(6):5427-30. doi: 10.1007/s13277-014-1707-5. Epub 2014 Feb 13.
Several case-control studies indicated that XRCC3 genetic polymorphism (C722T) was associated with larynx cancer. The present study aimed to further evaluate the relation between the XRCC3 gene C722T polymorphism and larynx cancer. We selected five case-control studies related to XRCC3 gene C722T polymorphism and larynx cancer by searching PubMed, EMBase, Chinese CNKI, and Wanfang database. RevMan 5.0 software was used to perform the analysis. We directly utilized Q test and I (2) test to test the heterogeneity between each study. We utilized the fixed effects model to merge the odds ratio (OR) and 95 % confidence interval. There were 1,507 larynx cancer patients and 3,623 cancer-free control subjects included in the present study. By meta-analysis, we did not find any association of XRCC3 gene C722T polymorphism with larynx cancer [OR=1.54, 95 % CI (0.77-3.08); P=0.22]. The present study indicated that XRCC3 gene C722T polymorphism was not associated with larynx cancer.
多项病例对照研究表明，XRCC3基因多态性（C722T）与喉癌有关。本研究旨在进一步评估XRCC3基因C722T多态性与喉癌之间的关系。我们通过检索PubMed、EMBase、中国知网和万方数据库，选取了五项与XRCC3基因C722T多态性和喉癌相关的病例对照研究。使用RevMan 5.0软件进行分析。我们直接采用Q检验和I²检验来检验各研究之间的异质性。我们采用固定效应模型合并比值比（OR）和95%置信区间。本研究纳入了1507例喉癌患者和3623例无癌对照受试者。通过荟萃分析，我们未发现XRCC3基因C722T多态性与喉癌有任何关联[OR = 1.54，95%CI（0.77 - 3.08）；P = 0.22]。本研究表明，XRCC3基因C722T多态性与喉癌无关。
Zotero 插件