Kirmani Batool F, Mungall-Robinson Diana
Department of Neurology, Epilepsy Center, Scott & White Neuroscience Institute, Texas A&M Health Science Center College of Medicine , Temple, TX , USA.
Front Neurol. 2014 Jan 30;5:10. doi: 10.3389/fneur.2014.00010. eCollection 2014.
Seventy percent of the AIDS patients have neurological complications. Seizures are one of the complications and can occur at any stage. Seizures can be life-threatening and treatment with anticonvulsants is warranted. The therapeutic dilemma occurs in this case because of the interactions between the anticonvulsants, especially the first generation anticonvulsants, with antiretroviral agents resulting in significant side-effects including toxicity. The non-availability of second-generation anticonvulsants and cost constraints further limit the choices for the physicians. In this mini-review, we discuss the management of AIDS related seizures with emphasis on the drug-drug interactions between anticonvulsants and antiretroviral agents. We will also address the future directions and the need for prospective studies with second-generation anticonvulsants.
70%的艾滋病患者有神经并发症。癫痫发作是其中一种并发症，可在任何阶段发生。癫痫发作可能危及生命，因此有必要使用抗惊厥药物进行治疗。在这种情况下会出现治疗困境，因为抗惊厥药物，尤其是第一代抗惊厥药物，与抗逆转录病毒药物之间存在相互作用，会导致包括毒性在内的严重副作用。第二代抗惊厥药物的缺乏以及成本限制进一步限制了医生的选择。在这篇小型综述中，我们讨论艾滋病相关癫痫发作的管理，重点是抗惊厥药物与抗逆转录病毒药物之间的药物相互作用。我们还将探讨未来的方向以及对第二代抗惊厥药物进行前瞻性研究的必要性。
