集落刺激因子与癌症。
The colony-stimulating factors and cancer.
机构信息
Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville 3010, Victoria, Australia. Telephone: 61-3-9345-2555;
出版信息
Cancer Immunol Res. 2013 Dec;1(6):351-6. doi: 10.1158/2326-6066.CIR-13-0151.
Abstract
The colony-stimulating factors (CSFs) are the master regulators of granulocyte and macrophage populations. There are four different aspects of the connection between the CSFs and cancer: (a) the CSFs can accelerate the regeneration of protective white cells damaged by chemotherapy; (b) the CSFs can mobilize stem cells to the peripheral blood in convenient numbers for transplantation; (c) the CSFs can enhance anticancer immune responses and (d) the CSFs are potentially involved in the genesis of the myeloid leukemias.
摘要
集落刺激因子（CSFs）是粒细胞和巨噬细胞群体的主要调节因子。CSFs 与癌症之间存在着四个不同的联系方面：（a）CSFs 可以加速化疗损伤的保护性白细胞的再生；（b）CSFs 可以动员干细胞进入外周血，以便进行方便的移植；（c）CSFs 可以增强抗肿瘤免疫反应；（d）CSFs 可能参与髓性白血病的发生。
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