The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
Nat Rev Cancer. 2010 Jun;10(6):425-34. doi: 10.1038/nrc2843.
The four colony-stimulating factors (CSFs) are glycoproteins that regulate the generation and some functions of infection-protective granulocytes and macrophages. Recombinant granulocyte-CSF (G-CSF) and granulocyte-macrophage-CSF (GM-CSF) have now been used to increase dangerously low white blood cell levels in many millions of cancer patients following chemotherapy. These CSFs also release haematopoietic stem cells to the peripheral blood, and these cells have now largely replaced bone marrow as more effective populations for transplantation to cancer patients who have treatment-induced bone marrow damage.
四种集落刺激因子(CSFs)是糖蛋白,可调节抗感染保护粒细胞和巨噬细胞的生成和某些功能。重组粒细胞集落刺激因子(G-CSF)和粒细胞-巨噬细胞集落刺激因子(GM-CSF)现已用于增加化疗后数百万癌症患者危险的白细胞水平降低。这些 CSF 还将造血干细胞释放到外周血中,这些细胞现在已在很大程度上取代骨髓,成为更有效的移植群体,用于治疗引起骨髓损伤的癌症患者。