Hagenlocher Yvonne, Lorentz Axel
Department of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, D-70593 Stuttgart, Germany.
Department of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, D-70593 Stuttgart, Germany.
Mol Immunol. 2015 Jan;63(1):25-31. doi: 10.1016/j.molimm.2013.12.005. Epub 2014 Feb 11.
In the past decades an increasing prevalence of allergic disorders was observed in industrialized countries. Thus, it is necessary to develop adequate therapeutic and preventive strategies. Many of the conservative strategies possess diverse harmful side effects. Therefore agents with fewer side effects and a better compliance among afflicted patients would be of interest. Especially substances with natural origin acting immunomodulatory on mast cells - the key effector cells of allergic diseases - could be used. Among them there are components of the daily diet such as distinct fatty acids and amino acids as well as a range of secondary plant substances such as carotenoids, flavonoids and spices. These nutritional substances could be applied as nutraceuticals in the therapy of mast cell associated diseases. Many of these substances show inhibitory influences on the release of prestored mast cell mediators such as histamine or de novo expression of mast cell mediators such as cytokines and eicosanoids which are involved in the pathogenesis of mast cell associated inflammatory conditions like allergic reactions.
在过去几十年里，工业化国家中过敏性疾病的患病率呈上升趋势。因此，有必要制定适当的治疗和预防策略。许多保守策略都有各种各样的有害副作用。所以，副作用较少且患者依从性较好的药物会受到关注。特别是对肥大细胞（过敏性疾病的关键效应细胞）具有免疫调节作用的天然物质可以被利用。其中包括日常饮食中的成分，如特定的脂肪酸和氨基酸，以及一系列次生植物物质，如类胡萝卜素、黄酮类化合物和香料。这些营养物质可以作为营养保健品应用于肥大细胞相关疾病的治疗。这些物质中的许多对预先储存的肥大细胞介质（如组胺）的释放或肥大细胞介质（如细胞因子和类花生酸）的从头表达具有抑制作用，而这些介质参与了肥大细胞相关炎症性疾病（如过敏反应）的发病机制。
