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海绵窦血管瘤:一家机构十四年的单中心经验。

Cavernous sinus hemangioma: a fourteen year single institution experience.

机构信息

Department of Neurosurgery, Neurosciences Center, All India Institute of Medical Sciences, New Delhi 110029, India.

Department of Neurosurgery, Neurosciences Center, All India Institute of Medical Sciences, New Delhi 110029, India.

出版信息

J Clin Neurosci. 2014 Jun;21(6):968-74. doi: 10.1016/j.jocn.2013.09.008. Epub 2013 Nov 6.

DOI:10.1016/j.jocn.2013.09.008
PMID:24524951
Abstract

Cavernous sinus hemangioma (CSH) is a rare extra-axial vascular neoplasm that accounts for 2% to 3% of all cavernous sinus tumors. Their location, propensity for profuse bleeding during surgery, and relationship to complex neurovascular structures are factors which present difficulty in excising these lesions. The authors describe their experience of 22 patients with CSH over 14 years at a tertiary care center. Patients were managed with microsurgical resection using a purely extradural transcavernous approach (13 patients) and with Gamma Knife radiosurgery (GKRS; Elekta AB, Stockholm, Sweden) (nine patients). Retrospective data analysis found headache and visual impairment were the most common presenting complaints, followed by facial hypesthesia and diplopia. All but one patient had complete tumor excision in the surgical series. Transient ophthalmoparesis (complete resolution in 6-8 weeks) was the most common surgical complication. In the GKRS group, marked tumor shrinkage (>50% tumor volume reduction) was achieved in two patients, slight shrinkage in five and no change in two patients, with symptom improvement in the majority of patients. To our knowledge, we describe one of the largest series of CSH managed at a single center. Although microsurgical resection using an extradural transcavernous approach is considered the treatment of choice in CSH and allows complete excision with minimal mortality and long-term morbidity, GKRS is an additional tool for treating residual symptomatic lesions or in patients with associated comorbidities making surgical resection unsuitable.

摘要

海绵窦血管瘤(CSH)是一种罕见的颅外轴外血管性肿瘤,占所有海绵窦肿瘤的 2%至 3%。其位置、手术过程中大量出血的倾向以及与复杂的神经血管结构的关系是切除这些病变的困难因素。作者描述了他们在一家三级护理中心 14 年期间治疗 22 例 CSH 患者的经验。患者采用单纯经颅外海绵窦入路的显微切除术(13 例)和伽玛刀放射外科治疗(GKRS;Elekta AB,斯德哥尔摩,瑞典)(9 例)进行治疗。回顾性数据分析发现,头痛和视力障碍是最常见的首发症状,其次是面部感觉减退和复视。手术组除 1 例外,所有患者均完全切除肿瘤。暂时性动眼神经麻痹(6-8 周完全缓解)是最常见的手术并发症。在 GKRS 组中,2 例患者肿瘤明显缩小(>50%肿瘤体积减少),5 例患者肿瘤轻微缩小,2 例患者肿瘤无变化,大多数患者症状改善。据我们所知,我们描述了单一中心治疗的最大 CSH 系列之一。虽然经颅外海绵窦入路的显微切除术被认为是 CSH 的首选治疗方法,可以实现完全切除,死亡率和长期发病率低,但 GKRS 是治疗残留症状性病变或伴有相关合并症的患者的另一种工具,使手术切除不适合。

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