New Medicines Neurosciences Therapeutic Area Head, UCB Pharma, S.A., Belgium.
Curr Opin Pharmacol. 2014 Feb;14:97-102. doi: 10.1016/j.coph.2014.01.001. Epub 2014 Feb 11.
Schizophrenia might be considered a neurodevelopmental disease. However, the fundamental process(es) associated with this disease remain(s) uncertain. Many lines of evidence suggest that schizophrenia is associated with excessive stimulation of dopamine D2 receptors in the associative striatum, with a lack of stimulation of dopamine D1 receptors in prefrontal cortex, and with modifications in prefrontal neuronal connectivity involving glutamate transmission at N-methyl aspartate (NMDA) receptors. This article, whilst briefly discussing the current knowledge of the disease, mainly concentrates on the NMDA hypofunction hypothesis. However, there are also potential consequences for a Dopamine imbalance on NMDA function. Thus, it is proposed that schizophrenia has a complex aetiology associated with strongly interconnected aberrations of dopamine and glutamate transmission.
精神分裂症可能被认为是一种神经发育疾病。然而，与这种疾病相关的基本过程仍然不确定。许多证据表明，精神分裂症与联合纹状体中多巴胺 D2 受体的过度刺激有关，与前额叶皮层中多巴胺 D1 受体的刺激不足有关，以及涉及 N-甲基-D-天冬氨酸（NMDA）受体谷氨酸传递的前额叶神经元连接的改变有关。本文在简要讨论该疾病现有知识的同时，主要集中于 NMDA 功能低下假说。然而，多巴胺失衡对 NMDA 功能也可能产生潜在影响。因此，有人提出精神分裂症具有复杂的病因，与多巴胺和谷氨酸传递的强烈相互关联的异常有关。
