D'Addario Claudio, Di Bartolomeo Martina
Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Subcell Biochem. 2025;108:191-215. doi: 10.1007/978-3-031-75980-2_5.
Schizophrenia is a severe and complex psychiatric condition ranking among the top 15 leading causes of disability worldwide. Despite the well-established heritability component, a complex interplay between genetic and environmental risk factors plays a key role in the development of schizophrenia and psychotic disorders in general. This chapter covers all the clinical evidence showing how the analysis of the epigenetic modulation in schizophrenia might be relevant to understand the pathogenesis of schizophrenia as well as potentially useful to develop new pharmacotherapies.
精神分裂症是一种严重且复杂的精神疾病，在全球致残的主要原因中位列前15。尽管遗传因素已得到充分证实，但遗传和环境风险因素之间的复杂相互作用在精神分裂症及一般精神障碍的发病过程中起着关键作用。本章涵盖了所有临床证据，这些证据表明对精神分裂症表观遗传调控的分析对于理解精神分裂症的发病机制如何具有相关性，以及对于开发新的药物治疗可能如何有用。
