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精神分裂症患者淋巴细胞中DNA修复紊乱与疾病病程形式的关系

[Disordered DNA repair in the lymphocytes of patients with schizophrenia depending on the form of the course of the disease].

作者信息

Zharikov N M, Zasukhina G D, L'vova G N, Chekova V V, Vasil'eva I M

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(1):93-6.

PMID:2452540
Abstract

Employing the appropriate technique the authors have examined lymphocytes of 26 patients suffering from schizophrenia of different types. The study has shown distinct disorders of DNA reparation associated with this disease, which is suggestive of deficiency or noncoordination of the enzymatic system explained by mutations in corresponding genes. Disorders of DNA reparation have until recently been known to be associated only with hereditary diseases.

摘要

作者运用适当技术对26名不同类型精神分裂症患者的淋巴细胞进行了检测。研究表明,这种疾病存在与DNA修复明显相关的紊乱情况,这表明相应基因发生突变导致酶系统存在缺陷或不协调。直到最近人们才知道DNA修复紊乱仅与遗传性疾病有关。

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