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[γ射线、紫外线照射及放射模拟物对精神分裂症患者培养细胞修复活性的抑制作用]

[Inhibition of repair activity induced by gamma-, UV-irradiation and radiomimetics in cultured cells from schizophrenia patients].

作者信息

Zasukhina G D, Zharikov N M, L'vova G N, Vasil'eva I M, Chekova V V

出版信息

Radiobiologiia. 1986 Jan-Feb;26(1):56-60.

PMID:3081940
Abstract

A study was made of the processes of repair, virus reactivation, and formation of sister chromatid exchanges (SCE) in blood cells of patients with schizophrenia after the effect of gamma-radiation and 4-nitroquinoline-1-oxide. These processes were estimated by 12 criteria. The mutagen-induced disturbances in the processes of repair and SCE formation were found in cells of patients with schizophrenia and were absent in the control cells of healthy donors.

摘要

对精神分裂症患者血细胞在γ射线和4-硝基喹啉-1-氧化物作用后修复、病毒再激活及姐妹染色单体交换(SCE)形成过程进行了研究。这些过程通过12项标准进行评估。在精神分裂症患者细胞中发现了诱变剂诱导的修复和SCE形成过程中的紊乱,而健康供体的对照细胞中则未出现。

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