Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia.
Invest Ophthalmol Vis Sci. 2014 Mar 20;55(3):1763-9. doi: 10.1167/iovs.13-13320.
To assess factors associated with retinal oximetry values in healthy young adults.
Retinal oximetry readings were assessed using the oximetry module of the Vesselmap System in 100 eyes of 50 healthy subjects aged 18 to 58 years. Generalized estimating equation models were used to estimate the associations of candidate variables (age, sex, retinal capillary flow, HbA1c, triglyceride, total cholesterol, ocular perfusion pressure, and finger oxygen saturation [SO2]) with retinal oximetry measures (arteriolar SO2, venular SO2, and the arterio-venous [A-V] difference).
Of the candidate factors assessed, only age and finger SO2 were found to be significantly associated with one or more measures of retinal oximetry in unadjusted analyses. After adjusting for age, sex, and significant factors from unadjusted analyses, age and finger SO2 values remained significant. Age was associated with retinal arteriolar and venular SO2 values (per year increase in age, β = 0.31, 95% confidence interval [CI]: 0.15-0.48 and β = 0.26, 95% CI: 0.08-0.43, respectively), but not associated with the A-V difference. Finger SO2 values were associated with retinal arteriolar SO2 and A-V difference (per percentage change in finger SO2, β = 1.34, 95% CI: 0.40-2.28 and β = 0.74, 95% CI: 0.36-1.11, respectively), but not with venular SO2.
In healthy young adults, age was positively associated with the retinal arteriolar and venular SO2 values, whereas finger SO2 was positively correlated with greater arteriolar SO2 and A-V difference. Our findings serve as a basis for future studies assessing retinal oximetry values in young adults under normal and pathophysiological conditions.
评估健康年轻成年人视网膜血氧计值相关因素。
使用 Vesselmap 系统的血氧计模块对 50 名年龄在 18 至 58 岁的健康受试者的 100 只眼进行视网膜血氧计读数评估。使用广义估计方程模型来估计候选变量（年龄、性别、视网膜毛细血管流量、HbA1c、甘油三酯、总胆固醇、眼灌注压和手指血氧饱和度[SO2]）与视网膜血氧计测量值（动脉 SO2、静脉 SO2 和动静脉[AV]差值）的关联。
在所评估的候选因素中，仅年龄和手指 SO2 在未调整分析中被发现与一个或多个视网膜血氧计测量值显著相关。在调整年龄、性别和未调整分析中的显著因素后，年龄和手指 SO2 值仍然显著。年龄与视网膜动脉和静脉 SO2 值相关（每增加 1 岁，β=0.31，95%置信区间[CI]：0.15-0.48 和β=0.26，95%CI：0.08-0.43），但与 AV 差值无关。手指 SO2 值与视网膜动脉 SO2 和 AV 差值相关（手指 SO2 每变化 1%，β=1.34，95%CI：0.40-2.28 和β=0.74，95%CI：0.36-1.11），但与静脉 SO2 无关。
在健康的年轻成年人中，年龄与视网膜动脉和静脉 SO2 值呈正相关，而手指 SO2 值与较大的动脉 SO2 值和 AV 差值呈正相关。我们的发现为未来在正常和病理生理条件下评估年轻成年人视网膜血氧计值的研究提供了依据。
