Vellinga Akke, Zawiejska A, Harreiter J, Buckley B, Di Cianni G, Lapolla A, Corcoy R, Simmons D, Adelantado J M, Damm P, Desoye G, Devlieger R, Hill D, Kautzky-Willer A, Klemetti M, Mathiesen E, Rebollo P, Snoek F, Tikkanen M, Timmerman D, van Assche A, van Poppel M, Wender-Oegowska E, Dunne F
School of Medicine, Clinical Science Institute, National University of Ireland, Galway, Ireland.
Akademia Medyczna im Karola Marcinkowskiego, 60-512 Poznan, Poland.
ISRN Obes. 2012 Jun 12;2012:424010. doi: 10.5402/2012/424010. eCollection 2012.
Objective. Assess the impact of Gestational Diabetes Mellitus (GDM) and obesity on neonatal and maternal pregnancy outcomes. Methods. Cross-sectional data (3343 pregnancies) from seven European centres were included in a multilevel analysis of the association between GDM/obesity and caesarean section, macrosomia and neonatal morbidities. Results. Comparison of databases identified reporting differences between countries due to the inclusion of true population based samples or pregnancies from specialised tertiary centres, resulting in higher prevalences of GDM for some countries. The analysis showed that obesity and GDM were independent risk factors of perinatal complications. Only BMI had a dose-dependent effect on the risk of macrosomia and caesarean section. Both obesity (BMI > 30 kg/m(2)) and GDM were independent risk factors of neonatal morbidities. Conclusions. Obesity and GDM were independent risk factors of perinatal complications. The effect of the worldwide obesity and diabetes epidemic is extending to the next generation.
目的。评估妊娠期糖尿病（GDM）和肥胖对新生儿及孕产妇妊娠结局的影响。方法。来自七个欧洲中心的横断面数据（3343例妊娠）被纳入对GDM/肥胖与剖宫产、巨大儿及新生儿疾病之间关联的多水平分析。结果。数据库比较发现，由于纳入基于真实人群的样本或来自专科三级中心的妊娠，各国之间存在报告差异，导致部分国家GDM患病率较高。分析表明，肥胖和GDM是围产期并发症的独立危险因素。只有体重指数（BMI）对巨大儿和剖宫产风险有剂量依赖性影响。肥胖（BMI>30 kg/m²）和GDM都是新生儿疾病的独立危险因素。结论。肥胖和GDM是围产期并发症的独立危险因素。全球肥胖和糖尿病流行的影响正在延伸至下一代。
