Wang Pu, Wei Xiao-Fei, Yang Xiao-Tian, Zhou Yu-Jing, Liu Chuan, Ji Qiao-Dan, Yang Lin, He Cheng-Qi
Center of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Jan;45(1):111-5.
To investigate the effects of whole body vibration therapy (WBVT) on structural and functional remodeling of subchondral bone in rabbits with early Osteoarthritis (OA).
Twenty-four adult rabbits received anterior cruciate ligament transaction (ACLT) to establish knee osteoarthritis model. The rabbits were randomly divided into two groups: ACLT group and WBVT+ ACLT group. The rabbits in the WBVT+ ACLT group received whole body vibration treatment (Frequency: 40 Hz; Amplitude: 2-4 mm; 40 min/d, 5 d/week, 4 weeks) two months after surgery. After interventions, the left femur and tibia of all rabbits were placed in a Micro-CT scanning system. The bone volume fraction (BVF), trabecular thickness (Tb. Th), trabecular spacing (Tb. Sp), trabecular number (Tb. N), volumetric BMD (vBMD), and tissue BMD (tBMD) of the bones of femoral condyle and tibia were analysed using three-dimensional reconstruction Micview V2.1.2 and ABA analysis software. Geomagic Studio 11.0 software were used to calculate modulus (EM), reaction force (RF) and average Von Miss stress (VMF).
Higher levels of BVF, Tb. N, Tb. Th, EM, RF, VMF, vBMD and tBMD and lower levels of Tb. Sp were found in distal femora and tibia of the rabbits in the WBVT+ACLT group compared with the controls (P < 0.05).
WBVT can effectively improve bone microstructure and mechanical properties of rabbits with early knee osteoarthritis.
探讨全身振动疗法（WBVT）对早期骨关节炎（OA）家兔软骨下骨结构和功能重塑的影响。
24只成年家兔接受前交叉韧带切断术（ACLT）以建立膝骨关节炎模型。将家兔随机分为两组：ACLT组和WBVT + ACLT组。WBVT + ACLT组的家兔在术后两个月接受全身振动治疗（频率：40 Hz；振幅：2 - 4 mm；40分钟/天，5天/周，共4周）。干预后，将所有家兔的左股骨和胫骨置于微型计算机断层扫描（Micro - CT）系统中。使用三维重建Micview V2.1.2和ABA分析软件分析股骨髁和胫骨的骨体积分数（BVF）、骨小梁厚度（Tb.Th）、骨小梁间距（Tb.Sp）、骨小梁数量（Tb.N）、体积骨密度（vBMD）和组织骨密度（tBMD）。使用Geomagic Studio 11.0软件计算模量（EM）、反作用力（RF）和平均冯·米塞斯应力（VMF）。
与对照组相比，WBVT + ACLT组家兔股骨远端和胫骨的BVF、Tb.N、Tb.Th、EM、RF、VMF、vBMD和tBMD水平较高，Tb.Sp水平较低（P < 0.05）。
WBVT可有效改善早期膝骨关节炎家兔的骨微结构和力学性能。
