Dgani R, Shoham Z, Czernobilsky B, Kaftori A, Borenstein R, Lancet M
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Gynecol Oncol. 1988 May;30(1):44-50. doi: 10.1016/0090-8258(88)90044-3.
Pure dysgerminoma is considered to be a nonsecretary ovarian tumor. In this study serum lactic dehydrogenase, human chorionic gonadotropin, and alkaline phosphatase levels were highly elevated in a 21-year-old woman with unilateral ovarian pure dysgerminoma and fell sharply to normal levels after removal of the tumor. In order to establish the source of these elevated serum enzymes and hormone, the tumor was homogenized and the level of these substances was found to be several times higher than that of normal homogenized ovarian tissue. In addition, the presence of lactic dehydrogenase and alkaline phosphatase in the dysgerminoma cells was shown by histochemical methods. This is the first report providing evidence that pure dysgerminoma contains and secretes enzymes and hormones which may constitute tumor markers useful for the diagnosis and follow-up of patients with this type of neoplasm.
纯无性细胞瘤被认为是一种非分泌性卵巢肿瘤。在本研究中，一名21岁单侧卵巢纯无性细胞瘤女性的血清乳酸脱氢酶、人绒毛膜促性腺激素和碱性磷酸酶水平显著升高，肿瘤切除后这些水平急剧降至正常。为了确定这些血清酶和激素升高的来源，将肿瘤匀浆，发现这些物质的水平比正常匀浆的卵巢组织高几倍。此外，通过组织化学方法显示了无性细胞瘤细胞中存在乳酸脱氢酶和碱性磷酸酶。这是第一份提供证据表明纯无性细胞瘤含有并分泌酶和激素的报告，这些酶和激素可能构成对这类肿瘤患者诊断和随访有用的肿瘤标志物。
