Sheiko M C, Hart W R
Cancer. 1982 Mar 1;49(5):994-8. doi: 10.1002/1097-0142(19820301)49:5<994::aid-cncr2820490524>3.0.co;2-l.
lactic dehydrogenase (LDH) is a glycolytic enzyme that may be elevated in the serum of patients with gonadal and extragonadal germinomas. In this report, the authors describe a young woman with a unilateral ovarian pure germinoma (dysgerminoma) who had greater than a sixfold elevation of serum LDH levels with increases in LDH isoenzymes 1, 2, and 3. Two weeks after operation, the serum LDH level had returned to normal. Four additional examples of ovarian germinoma with elevated serum LDH levels have been recorded in the literature. The germinoma cells are the likely source of the elevated LDH activity in such cases. Lactic dehydrogenase and its isoenzymes may serve as a useful tumor marker for diagnosis and posttherapy surveillance in patients with germinomas (dysgerminomas, seminomas). The association of elevated serum LDH in patients with other neoplasms is also reviewed.
乳酸脱氢酶（LDH）是一种糖酵解酶，在性腺和性腺外生殖细胞瘤患者的血清中可能会升高。在本报告中，作者描述了一名患有单侧卵巢纯生殖细胞瘤（无性细胞瘤）的年轻女性，其血清LDH水平升高超过六倍，同时LDH同工酶1、2和3也升高。术后两周，血清LDH水平恢复正常。文献中还记录了另外4例血清LDH水平升高的卵巢生殖细胞瘤病例。在这些病例中，生殖细胞瘤细胞可能是LDH活性升高的来源。乳酸脱氢酶及其同工酶可作为生殖细胞瘤（无性细胞瘤、精原细胞瘤）患者诊断和治疗后监测的有用肿瘤标志物。本文还综述了其他肿瘤患者血清LDH升高的相关性。
