Babacan Nalan Akgul, Yucel Birsen, Kilickap Saadettin, Seker Mehmet Metin, Kacan Turgut, Olcas Ilknur Koc, Eren Ayfer Ay, Odabas Hatice
Departments of Medical Oncology, University of Cumhuriyet, SIVAS, Turkey E-mail :
Asian Pac J Cancer Prev. 2014;15(1):151-4. doi: 10.7314/apjcp.2014.15.1.151.
Lung cancer is the most common cause of cancer-related death worldwide. The incidence of lung cancer is aproximately 7-8 thousand percent in Turkish women. In this study, we aimed to evaluate the clinical, pathological properties and survival data of female patients with lung cancer who were treated in our center.
From 2007 to 2012, 50 women with lung cancer were enrolled. Patient data were evaluated retrospectively.
The median age was 61 (40-81). Forty patients (80%) were diagnosed with non small cell lung cancer (NSCLC), 10 patients (20%) were small cell carcinoma (SCC). Twelve (24%) patients were smokers and 13 of 16 non-smokers had a history of exposure to asbestos. The most common histologic subtype was adenocarcinoma (46%) and this accounted for 71% in patients with exposure to asbestos. The most common initial Eastern Cooperative Oncology Group (ECOG) performance score was 1 (24 patients, 48%) and initial stage was IV (25 patients, 50%) in the study group. During the median 15 months (1-96 months) followup period: 1 year overall survival (OS) was 68%, 2year overall survival was 36% and the median survival time was 19 months. According to univariate analysis, poor ECOG performance status, advanced stage, anemia and weight loss at time of diagnosis were negative prognostic factors. However, adenocarcinoma sub-type was a positive prognostic factor.
In this study NSCLC sub-type, poor ECOG performance score, advanced stage, anemia and weight loss were prognostic factors in Turkish women with lung cancer.
肺癌是全球癌症相关死亡的最常见原因。土耳其女性肺癌发病率约为7 - 8千分之一。在本研究中，我们旨在评估在我们中心接受治疗的女性肺癌患者的临床、病理特征及生存数据。
2007年至2012年，纳入50例女性肺癌患者。对患者数据进行回顾性评估。
中位年龄为61岁（40 - 81岁）。40例（80%）患者被诊断为非小细胞肺癌（NSCLC），10例（20%）为小细胞癌（SCC）。12例（24%）患者吸烟，16例不吸烟者中有13例有石棉接触史。最常见的组织学亚型是腺癌（46%），在石棉接触患者中占71%。研究组中最常见的初始东部肿瘤协作组（ECOG）体能状态评分为1分（24例患者，48%），初始分期为IV期（25例患者，50%）。在中位15个月（1 - 96个月）的随访期内：1年总生存率（OS）为68%，2年总生存率为36%，中位生存时间为19个月。单因素分析显示，ECOG体能状态差、晚期、诊断时贫血和体重减轻是不良预后因素。然而，腺癌亚型是一个良好的预后因素。
在本研究中，NSCLC亚型、ECOG体能状态评分差、晚期、贫血和体重减轻是土耳其女性肺癌的预后因素。
