中国和印度谷胱甘肽S-转移酶T1和M1基因缺失型与口腔癌易感性的荟萃分析
Null Glutathione S-transferase T1 and M1 genotypes and oral cancer susceptibility in China and India--a meta-analysis.
作者信息
Peng Jie, Liu Hong-Zhou, Zhu You-Jia
机构信息
Clinical Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, China E-mail :
出版信息
Asian Pac J Cancer Prev. 2014;15(1):287-90. doi: 10.7314/apjcp.2014.15.1.287.
OBJECTIVE
Genetic variation is considered to strongly impact on detoxification of carcinogens and therefore is related to cancer risk. However, findings for the null genotypes of GSTT1 and GSTM1 have not always been consistent. Therefore the present meta-analysis was conducted.
METHODS
We accessed the reported study at different research areas and used various databases, including PubMed and Wanfang Med Onlion from 1990 to May 1st 2013. We calculated the odds ratio (OR), 95% confidence interval (CI) and P value for oral cancer by using Review Manager 5.1 and STATE 12.
RESULTS
We found that there was no increased oral cancer risk among subjects carrying GSTM1 and GSTT1 null genotype (OR=1.35, 95%CI=0.68-2.68, P=0.39) and (OR=1.41, 95%CI=0.72-2.77, P=0.31) in the Chinese population. In contrast, in studies in India a significant correlation between GSTM1 null genotype and oral cancer was observed (OR=1.59, 95%CI=1.20-2.11, P=0.001), but not in GSTT1 (OR=1.21, 95% CI = 0.84-1.74, P=0.31).
CONCLUSION
We discovered that GSTM1 deletion polymorphism had a significant effect on the susceptibility of oral cancer in the Indian population.
目的
基因变异被认为对致癌物的解毒作用有强烈影响，因此与癌症风险相关。然而，谷胱甘肽S-转移酶T1（GSTT1）和谷胱甘肽S-转移酶M1（GSTM1）零基因型的研究结果并不总是一致的。因此进行了本荟萃分析。
方法
我们检索了不同研究领域的已报道研究，并使用了包括1990年至2013年5月1日期间的PubMed和万方医学在线等各种数据库。我们使用Review Manager 5.1和STATE 12计算了口腔癌的比值比（OR）、95%置信区间（CI）和P值。
结果
我们发现，在中国人群中，携带GSTM1和GSTT1零基因型的受试者患口腔癌的风险没有增加（OR = 1.35，95%CI = 0.68 - 2.68，P = 0.39）以及（OR = 1.41，95%CI = 0.72 - 2.77，P = 0.31）。相比之下，在印度的研究中，观察到GSTM1零基因型与口腔癌之间存在显著相关性（OR = 1.59，95%CI = 1.20 - 2.11，P = 0.001），但在GSTT1中未观察到（OR = 1.21, 95% CI = 0.84 - 1.74, P =
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