谷胱甘肽S-转移酶M1基因缺失型与中国和印度肝细胞癌易感性：一项更新的荟萃分析证据

Glutathione S-transferase M1 null genotype and hepatocellular carcinoma susceptibility in China and India: evidence from an updated meta-analysis.

作者信息

Liu Hong-Zhou, Peng Jie, Peng Chun-Yan, Yan Ming, Zheng Fang

机构信息

Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University Wuhan, China E-mail :

出版信息

Asian Pac J Cancer Prev. 2014;15(12):4851-6. doi: 10.7314/apjcp.2014.15.12.4851.

DOI:10.7314/apjcp.2014.15.12.4851

PMID:24998552

Abstract

BACKGROUND

Glutathione S-transferase M1 (GSTM1) have been reported to be associated with hepatocellular carcinoma. However, the effect of the GSTM1 null genotype was divergent in the literature and we therefore performed the present meta-analysis to explore the relationship in detail.

MATERIALS AND METHODS

Reported studies were searched from 1990 to March 1, 2014 in PubMed and Wanfang Med Online. The total odds oatio (OR) and 95% CI were calculated and analyzed by Review Manager 5.1 and STATE 12.

RESULTS

Total OR was calculated from 26 articles with 3,769 cases and 5,517 controls and the association proved significant (OR [95%CI]=1.50 [1.25, 1.80], P<0.05) in the Chinese population. However, there was no significant association between hepatocellular carcinoma risk among subjects carrying the GSTM1 null genotype (OR [95%CI]=1.20 [0.88-1.64], P=0.24) in subgroups of publication in English and in Indian populations (OR [95%CI]=1.80 [0.80- 4.20], P=0.15).

CONCLUSIONS

The GSTM1 deletion polymorphism might not have a significant effect on the susceptibility of hepatocellular carcinoma overall.

摘要

背景

据报道，谷胱甘肽S-转移酶M1（GSTM1）与肝细胞癌有关。然而，GSTM1基因缺失型的影响在文献中存在分歧，因此我们进行了本荟萃分析以详细探讨其关系。

材料与方法

在PubMed和万方医学在线上检索1990年至2014年3月1日发表的相关研究。通过Review Manager 5.1和STATE 12计算并分析总比值比（OR）和95%置信区间（CI）。

结果

从26篇文章中计算得出总OR，涉及3769例病例和5517例对照，在中国人群中该关联具有统计学意义（OR [95%CI]=1.50 [1.25, 1.80]，P<0.05）。然而，在英文发表文章的亚组以及印度人群中，携带GSTM1基因缺失型的受试者患肝细胞癌风险之间无显著关联（OR [95%CI]=1.20 [0.88 - 1.64]，P=0.24）（OR [95%CI]=1.80 [0.80 - 4.20]，P=0.15）。