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TO901317, a potent LXR agonist, is an inverse agonist of CAR.TO901317,一种有效的 LXR 激动剂,是 CAR 的反向激动剂。
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Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.核受体介导的肠道和肝脏中药物和胆汁酸转运蛋白的调节。
Drug Metab Rev. 2013 Feb;45(1):48-59. doi: 10.3109/03602532.2012.748793.
3
Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond.雌激素相关受体在乳腺癌中的作用:细胞代谢的调控及其他。
Nat Rev Cancer. 2013 Jan;13(1):27-36. doi: 10.1038/nrc3396. Epub 2012 Nov 29.
4
Mechanisms of thyroid hormone action.甲状腺激素作用机制。
J Clin Invest. 2012 Sep;122(9):3035-43. doi: 10.1172/JCI60047. Epub 2012 Sep 4.
5
HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.通过高通量筛选人胰岛素启动子调节剂发现的HNF4α拮抗剂。
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PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty.过氧化物酶体增殖物激活受体-γ 作为心血管疾病的治疗靶点:证据与不确定性。
J Lipid Res. 2012 Sep;53(9):1738-54. doi: 10.1194/jlr.R024505. Epub 2012 Jun 8.
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Mol Cell Endocrinol. 2013 Apr 10;368(1-2):17-29. doi: 10.1016/j.mce.2012.05.004. Epub 2012 May 17.
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Pregnane X receptor as a target for treatment of inflammatory bowel disorders. pregnane X 受体作为治疗炎症性肠病的靶点。
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Clin Cancer Res. 2012 Jun 15;18(12):3223-8. doi: 10.1158/1078-0432.CCR-11-2953. Epub 2012 May 7.
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Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.核受体通过调节药物代谢酶和药物转运体在多药耐药中的作用。
Biochem Pharmacol. 2012 Apr 15;83(8):1112-26. doi: 10.1016/j.bcp.2012.01.030. Epub 2012 Feb 4.

《2013/14药理学简明指南:核激素受体》

The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors.

作者信息

Alexander Stephen P H, Benson Helen E, Faccenda Elena, Pawson Adam J, Sharman Joanna L, Spedding Michael, Peters John A, Harmar Anthony J

机构信息

School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

出版信息

Br J Pharmacol. 2013 Dec;170(8):1652-75. doi: 10.1111/bph.12448.

DOI:10.1111/bph.12448
PMID:24528240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3892290/
Abstract

The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full. Nuclear hormone receptors are one of the seven major pharmacological targets into which the Guide is divided, with the others being G protein-coupled receptors, ligand-gated ion channels, ion channels, catalytic receptors, transporters and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets. It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in previous Guides to Receptors and Channels. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and the Guide to Receptors and Channels, providing a permanent, citable, point-in-time record that will survive database updates.

摘要

《2013/14药理学简明指南》简要概述了2000多种人类药物靶点的关键特性及其药理学,还提供了药物靶点及其配体开放获取知识库(www.guidetopharmacology.org)的链接,该知识库提供了靶点和配体特性的更详细视图。完整内容可在http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full上查阅。核激素受体是该指南划分的七个主要药理学靶点之一,其他靶点包括G蛋白偶联受体、配体门控离子通道、离子通道、催化受体、转运体和酶。书中给出了命名指南以及关于现有最佳药理学工具的总结信息,同时列出了关键参考文献和进一步阅读建议。一种新的页面布局采用便于使用的表格来比较相关靶点。它是2013年末当代资料的精简版,在网站www.guidetopharmacology.org上有更详细的呈现且不断更新,取代了之前《受体与通道指南》中的数据。它是与NC-IUPHAR联合编写的,在适当情况下提供人类药物靶点的官方IUPHAR分类和命名。它整合了之前在IUPHAR-DB以及《受体与通道指南》中分别整理和展示的信息,提供了一份永久性的、可引用的、特定时间点的记录,即使数据库更新也能留存。