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转录因子 7 样 2（TCF7L2）基因多态性 rs7903146 与病程长的 2 型糖尿病患者中风有关。

Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration.

机构信息

Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea.

Department of Biochemistry, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea.

出版信息

Diabetes Res Clin Pract. 2014 Mar;103(3):e3-6. doi: 10.1016/j.diabres.2013.12.051. Epub 2014 Jan 15.

DOI:10.1016/j.diabres.2013.12.051
PMID:24529562
Abstract

Associations between TCF7L2 SNP and diabetic complications and diabetes-related factors were investigated. Subjects with rs7903146 variant had significantly higher prevalence of stroke (24.1% vs. 11.1%; P=0.039) among subjects exhibiting a long disease duration (≥10 years). In conclusion, the TCF7L2 SNP variant may confer a higher risk of stroke in diabetic patients.

摘要

研究了 TCF7L2 SNP 与糖尿病并发症和糖尿病相关因素之间的关联。在疾病持续时间≥10 年的受试者中，携带 rs7903146 变异的受试者中风的患病率明显更高（24.1%比 11.1%；P=0.039）。总之，TCF7L2 SNP 变异可能使糖尿病患者发生中风的风险更高。

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