Tan Ping-Heng, Pao Yun-Ying, Cheng Jen-Kun, Hung Kuo-Chuan, Liu Chien-Cheng
Department of Anesthesiology, E-Da Hospital, Kaohsiung, Taiwan; School of Medicine, I-Shou University, Kaohsiung, Taiwan.
Department of Anesthesiology, E-Da Hospital, Kaohsiung, Taiwan.
Acta Anaesthesiol Taiwan. 2013 Dec;51(4):171-6. doi: 10.1016/j.aat.2013.11.001. Epub 2013 Dec 25.
MicroRNAs (miRNAs) are small noncoding RNA molecules of 18-25 nucleotides in length that regulate gene expression involved in fundamental cell processes. The induction and chronification of pain is associated with many expressional changes in pain-related proteins. miRNA has the potential to regulate gene and protein expression associated with the induction and chronification of pain. Thus, miRNAs might have promise in therapy and as a diagnostic and prognostic biomarker in pain medicine. The application of miRNA has been an emerging field in pain research in recent years. Many studies focusing on the regulation of miRNAs under different tissue and nociceptive stimuli have been performed in recent years. In this review, we intend to introduce the most recent research in the field of miRNA related with pain medicine such as the expression and function of miRNA in different animal pain model, the challenge of application and delivery of miRNA in vivo, the potential toxic effects of miRNA and future problems in clinical application that need to be resolved. This review focuses on the results of miRNA in animal studies and the prospect for future success.
微小RNA（miRNA）是长度为18 - 25个核苷酸的小型非编码RNA分子，可调节参与基本细胞过程的基因表达。疼痛的诱导和慢性化与疼痛相关蛋白的许多表达变化有关。miRNA具有调节与疼痛诱导和慢性化相关的基因和蛋白质表达的潜力。因此，miRNA在疼痛医学的治疗以及作为诊断和预后生物标志物方面可能具有前景。近年来，miRNA的应用一直是疼痛研究中的一个新兴领域。近年来已经进行了许多针对不同组织和伤害性刺激下miRNA调控的研究。在本综述中，我们打算介绍与疼痛医学相关的miRNA领域的最新研究，例如miRNA在不同动物疼痛模型中的表达和功能、miRNA在体内应用和递送的挑战、miRNA的潜在毒性作用以及临床应用中需要解决的未来问题。本综述重点关注miRNA在动物研究中的结果以及未来成功的前景。
