Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
J Neuroimmunol. 2014 Mar 15;268(1-2):1-12. doi: 10.1016/j.jneuroim.2014.01.014. Epub 2014 Feb 4.
The Toll-like receptors (TLRs) are a family of microbe-sensing receptors that play a central role in the regulation of the host immune system. TLR4 has been described in the brain and seems to regulate some physiological processes, such as neurogenesis. TLR4 has also been reported to play a role during neurodegenerative disorders, including Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis and Parkinson's disease. This review is focused on reports concerning recent insights into the role and activation mechanisms of TLR4 in the brain, in pathological and physiological conditions, as well as the therapeutic benefit that could derive from TLR4 modulation.
Toll 样受体 (TLRs) 是一组微生物感应受体，在宿主免疫系统的调节中起着核心作用。TLR4 已在大脑中被描述，并似乎调节一些生理过程，如神经发生。TLR4 也被报道在神经退行性疾病中发挥作用，包括阿尔茨海默病、肌萎缩侧索硬化症、多发性硬化症和帕金森病。本综述重点介绍了有关 TLR4 在大脑中的作用和激活机制的最新研究进展，包括在病理和生理条件下，以及 TLR4 调节可能带来的治疗益处。
