被忽视的流行病：HIV/AIDS 中的真菌感染。
A neglected epidemic: fungal infections in HIV/AIDS.
机构信息
Imperial Fungal Diseases Group, Imperial College London, Department of Infectious Diseases and Immunity, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925 Cape Town, South Africa.
出版信息
Trends Microbiol. 2014 Mar;22(3):120-7. doi: 10.1016/j.tim.2014.01.001. Epub 2014 Feb 13.
Invasive fungal infections (IFIs) are a major cause of HIV-related mortality globally. Despite widespread rollout of combined antiretroviral therapy, there are still up to 1 million deaths annually from IFIs, accounting for 50% of all AIDS-related death. A historic failure to focus efforts on the IFIs that kill so many HIV patients has led to fundamental flaws in the management of advanced HIV infection. This review, based on the EMBO AIDS-Related Mycoses Workshop in Cape Town in July 2013, summarizes the current state of the-art in AIDS-related mycoses, and the key action points required to improve outcomes from these devastating infections.
侵袭性真菌感染（IFI）是全球导致 HIV 相关死亡的主要原因。尽管广泛推广了联合抗逆转录病毒疗法，但每年仍有多达 100 万人死于 IFI，占所有艾滋病相关死亡的 50%。历史上未能集中精力治疗导致如此多 HIV 患者死亡的 IFI，导致了晚期 HIV 感染管理中的根本缺陷。这篇综述基于 2013 年 7 月在开普敦举行的 EMBO 艾滋病相关真菌病研讨会，总结了艾滋病相关真菌病的最新进展，以及改善这些破坏性感染结局所需的关键行动要点。
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