Chen Tai-Di, Lee Li-Yu
Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Guishan Township, Taoyuan County, Taiwan, ROC.
Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Guishan Township, Taoyuan County, Taiwan, ROC.
J Formos Med Assoc. 2014 Feb;113(2):133-6. doi: 10.1016/j.jfma.2012.07.022. Epub 2012 Sep 4.
Tumor-to-tumor metastasis is an uncommon but well-documented phenomenon. We present a case of a clear cell renal cell carcinoma (RCC) metastasizing to an invasive ductal carcinoma (IDC) of the breast. A 74-year-old woman with a past history of clear cell RCC status after radical nephrectomy underwent right modified radical mastectomy for an enlarging breast mass 3 years after nephrectomy. Histological examination revealed a small focus with distinct morphological features similar to clear cell RCC encased in the otherwise typical IDC. Immunohistochemical studies showed that this focus was positive for CD10 and vimentin, in contrast to the surrounding IDC, which was negative for both markers and positive for Her2/neu. Based on the histological and immunohistochemical features, the patient was diagnosed with metastasis of clear cell RCC to the breast IDC. To the best of our knowledge, this is the first reported case of a breast neoplasm as the recipient tumor in tumor-to-tumor metastasis.
肿瘤-to-肿瘤转移是一种罕见但有充分文献记载的现象。我们报告一例透明细胞肾细胞癌（RCC）转移至乳腺浸润性导管癌（IDC）的病例。一名74岁女性，既往有透明细胞RCC病史，在根治性肾切除术后3年，因乳腺肿块增大接受了右改良根治性乳房切除术。组织学检查发现一个小病灶，其形态特征与典型IDC中包裹的透明细胞RCC相似。免疫组织化学研究显示，与周围IDC不同，该病灶CD10和波形蛋白呈阳性，而周围IDC这两种标志物均为阴性，Her2/neu呈阳性。根据组织学和免疫组织化学特征，该患者被诊断为透明细胞RCC转移至乳腺IDC。据我们所知，这是首例报道的以乳腺肿瘤作为肿瘤-to-肿瘤转移中接受转移肿瘤的病例。
