Gualano Bruno, Macedo André Regis, Alves Christiano Robles Rodrigues, Roschel Hamilton, Benatti Fabiana Braga, Takayama Liliam, de Sá Pinto Ana Lucia, Lima Fernanda Rodrigues, Pereira Rosa Maria Rodrigues
School of Medicine, Division of Rheumatology, University of São Paulo, Brazil; School of Physical Education and Sport, University of São Paulo, Brazil.
School of Medicine, Division of Rheumatology, University of São Paulo, Brazil.
Exp Gerontol. 2014 May;53:7-15. doi: 10.1016/j.exger.2014.02.003. Epub 2014 Feb 13.
This study aimed to examine the efficacy of creatine supplementation, associated or not with resistance training, in vulnerable older women. A 24-week, double-blind, randomized, placebo-controlled trial was performed. Sixty subjects were assigned to compose the following groups: placebo (PL), creatine supplementation (CR), placebo with resistance training (PL+RT), and creatine supplementation with resistance training (CR+RT). The subjects were assessed at baseline and after 24weeks. The primary outcome was muscle strength, as assessed by one-repetition maximum (1-RM) tests. Secondary outcomes included appendicular lean mass, bone mass, biochemical bone markers, and physical function tests. The changes in 1-RM leg press were significantly greater in the CR+RT group (+19.9%) than in the PL (+2.4%) and the CR groups (+3.7%), but not than in the PL+RT group (+15%) (p=0.002, p=0.002, and p=0.357, respectively). The CR+RT group showed superior gains in 1-RM bench press (+10%) when compared with all the other groups (p≤0.05). The CR+RT group (+1.31%) showed greater appendicular lean mass accrual than the PL (-1.2%), the CR (+0.3%), and the PL+RT groups (-0.2%) (p≤0.05). The CR and the PL+RT groups experienced comparable gains in appendicular lean mass (p=0.62), but superior to those seen in the PL group. Changes in fat mass, bone mass and serum bone markers did not significantly differ between the groups (p>0.05). In conclusion, creatine supplementation combined with resistance training improved appendicular lean mass and muscle function, but not bone mass, in older vulnerable women. Clinicaltrials.gov: NCT01472393.
本研究旨在探讨补充肌酸（无论是否联合抗阻训练）对体弱老年女性的功效。进行了一项为期24周的双盲、随机、安慰剂对照试验。60名受试者被分为以下几组：安慰剂组（PL）、补充肌酸组（CR）、安慰剂联合抗阻训练组（PL+RT）和补充肌酸联合抗阻训练组（CR+RT）。在基线和24周后对受试者进行评估。主要结局指标为肌肉力量，通过一次重复最大负荷（1-RM）测试进行评估。次要结局指标包括四肢瘦体重、骨量、生化骨标志物和身体功能测试。CR+RT组1-RM腿举的变化（+19.9%）显著大于PL组（+2.4%）和CR组（+3.7%），但不大于PL+RT组（+15%）（p分别为0.002、0.002和0.357）。与所有其他组相比，CR+RT组在1-RM卧推方面表现出更优的增长（+10%）（p≤0.05）。CR+RT组（+1.31%）的四肢瘦体重增加幅度大于PL组（-1.2%）、CR组（+0.3%）和PL+RT组（-0.2%）（p≤0.05）。CR组和PL+RT组在四肢瘦体重方面的增长相当（p=0.62），但优于PL组。各组之间的脂肪量、骨量和血清骨标志物变化无显著差异（p>0.05）。总之，在体弱老年女性中，补充肌酸联合抗阻训练可改善四肢瘦体重和肌肉功能，但对骨量无改善作用。Clinicaltrials.gov：NCT01472393。
