Erler Silvio, Lhomme Patrick, Rasmont Pierre, Lattorff H Michael G
Institut für Biologie, Molekulare Ökologie, Martin-Luther-Universität Halle-Wittenberg, Hoher Weg 4, 06099 Halle (Saale), Germany.
Laboratoire de Zoologie, Université de Mons, Place du Parc 20, 7000 Mons, Belgium.
Infect Genet Evol. 2014 Apr;23:129-37. doi: 10.1016/j.meegid.2014.02.002. Epub 2014 Feb 14.
Selection, as a major driver for evolution in host-parasite interactions, may act on two levels; the virulence of the pathogen, and the hosts' defence system. Effectors of the host defence system might evolve faster than other genes e.g. those involved in adaptation to changes in life history or environmental fluctuations. Host-parasite interactions at the level of hosts and their specific social parasites, present a special setting for evolutionarily driven selection, as both share the same environmental conditions and pathogen pressures. Here, we study the evolution of antimicrobial peptide (AMP) genes, in six host bumblebee and their socially parasitic cuckoo bumblebee species. The selected AMP genes evolved much faster than non-immune genes, but only defensin-1 showed significant differences between host and social parasite. Nucleotide diversity and codon-by-codon analyses confirmed that purifying selection is the main selective force acting on bumblebee defence genes.
作为宿主 - 寄生虫相互作用进化的主要驱动力，选择可能在两个层面起作用：病原体的毒力和宿主的防御系统。宿主防御系统的效应器可能比其他基因进化得更快，例如那些参与适应生活史变化或环境波动的基因。宿主及其特定社会寄生虫层面的宿主 - 寄生虫相互作用，为进化驱动的选择提供了特殊背景，因为它们共享相同的环境条件和病原体压力。在这里，我们研究了六种宿主大黄蜂及其社会寄生杜鹃大黄蜂物种中抗菌肽（AMP）基因的进化。所选的AMP基因比非免疫基因进化得快得多，但只有防御素 - 1在宿主和社会寄生虫之间表现出显著差异。核苷酸多样性和逐个密码子分析证实，纯化选择是作用于大黄蜂防御基因的主要选择力。
