Heckels J E, Virji M, Zak K, Fletcher J N
Dept. of Microbiology, University of Southampton, Medical School, Southampton General Hospital, UK.
Antonie Van Leeuwenhoek. 1987;53(6):461-4. doi: 10.1007/BF00415503.
Monoclonal antibodies have been obtained which react with gonococcal outer membrane protein I. One antibody recognised the majority of strains expressing P.IA and another recognised the majority of strains expressing P.IB. In in vitro tests both antibodies were bactericidal in the presence of complement, opsonic for phagocytosis by human PMN and protected epithelial cells against gonococcal invasion. Thus conserved epitopes on P.I. are potentially effective targets for immunoprophylaxis.
已经获得了与淋球菌外膜蛋白I发生反应的单克隆抗体。一种抗体识别出大多数表达P.IA的菌株，另一种识别出大多数表达P.IB的菌株。在体外试验中，两种抗体在补体存在时均具有杀菌作用，对人中性粒细胞的吞噬作用具有调理作用，并能保护上皮细胞免受淋球菌侵袭。因此，P.I上保守的表位可能是免疫预防的有效靶点。
