针对淋病奈瑟菌的血清型特异性免疫：它存在吗？
Serovar specific immunity to Neisseria gonorrhoeae: does it exist?
作者信息
Ross J D, Moyes A, Young H
机构信息
Department of Genitourinary Medicine, Edinburgh Royal Infirmary.
出版信息
Genitourin Med. 1995 Dec;71(6):367-9. doi: 10.1136/sti.71.6.367.
OBJECTIVE
To determine whether the host immune response to gonorrhoea provides limited serovar specific protection from reinfection.
SUBJECTS
508 episodes of gonorrhoea diagnosed at a city centre genitourinary medicine clinic including 22 patients with multiple infections over a 4 year period.
METHODS
Patients with recurrent gonococcal infection were analysed with respect to the initial and subsequent serovars isolated.
RESULTS
No significant difference was seen in the prevalence of serovars isolated following a repeat infection compared with those without repeat infections. The site of the initial infection did not appear to influence the subsequent serovar isolated.
CONCLUSION
We found no evidence of serovar specific immunity in our population. It remains possible that populations with a higher prevalence of gonorrhoea and more frequent infections may have a quantitatively greater immune response.
目的
确定宿主对淋病的免疫反应是否能提供有限的血清型特异性保护以防止再次感染。
研究对象
在市中心性传播疾病诊所诊断出的508例淋病病例，其中包括22例在4年期间发生多次感染的患者。
方法
对复发性淋球菌感染患者进行分析，比较初次和后续分离出的血清型。
结果
与未重复感染的患者相比，重复感染后分离出的血清型患病率没有显著差异。初次感染部位似乎不影响后续分离出的血清型。
结论
我们在研究人群中未发现血清型特异性免疫的证据。淋病患病率较高且感染更频繁的人群可能在数量上有更强的免疫反应，这种可能性仍然存在。
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