MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.
Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden.
Mol Med. 2014 Mar 24;20(1):135-7. doi: 10.2119/molmed.2014.00022.
High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activities, such as inducing chemotaxis or the transcription of cytokines and chemokines, via the interaction with different receptors. The different HMGB1 redox forms can be identified by mass spectrometry in body fluids of patients and may hold promise as biomarkers. We propose here a systematic nomenclature of the different redox forms of HMGB1 and related proteins, to replace the conflicting names used so far by different laboratories.
高迁移率族蛋白 B1（HMGB1）是炎症和免疫反应的重要介质。最近的研究表明，HMGB1 中三个半胱氨酸的不同氧化还原状态使其具有相互排斥的活性，例如通过与不同受体相互作用诱导趋化性或细胞因子和趋化因子的转录。不同的 HMGB1 氧化还原形式可以通过质谱法在患者的体液中识别出来，并可能成为有前途的生物标志物。在这里，我们提出了一种系统的 HMGB1 及其相关蛋白的不同氧化还原形式的命名法，以取代不同实验室迄今为止使用的相互冲突的名称。
