Xu Linlin, Huang Shaoyi, Chen Wei, Song Zhichun, Cai Shu
Department of Clinical Laboratory, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224001, China,
Tumour Biol. 2014 Jun;35(6):5181-7. doi: 10.1007/s13277-014-1672-z. Epub 2014 Feb 16.
Previous studies on the associations of the NFKB1 -94 insertion/deletion polymorphism with cancer risk have produced conflicting results. The purpose of this meta-analysis is to define the effect of the NFKB1 -94 insertion/deletion polymorphism on cancer risk. A search of the literature by PubMed was performed to identify studies based on the predetermined inclusion criteria. Twenty-three studies consisting of 6,494 cases and 9,884 controls were identified and analyzed. Overall, significant association was observed between the polymorphism and cancer risk under all genetic models. Subgroup analysis according to ethnicity and cancer type also detected significant association. The NFKB1 -94 insertion/deletion polymorphism was associated with cancer risk in Asian population (dominant model: OR=1.52, 95 % CI=1.17-1.98; recessive model: OR=1.50, 95 % CI=1.26-1.79; II vs. DD: OR=1.90, 95 % CI=1.37-2.65; ID vs. DD: OR=1.32, 95 % CI=1.05-1.66; I vs. D: OR=1.37, 95 % CI=1.17-1.60), but not in Caucasian population. In addition, significant associations in OC, HCC, and OSCC were observed, but significant associations were not found in BC and LC. The current meta-analysis suggested that NFKB1 -94 insertion/deletion polymorphism may influence cancer risk in Asian population.
先前关于NFKB1 -94插入/缺失多态性与癌症风险关联的研究结果相互矛盾。本荟萃分析的目的是确定NFKB1 -94插入/缺失多态性对癌症风险的影响。通过PubMed检索文献，以确定符合预定纳入标准的研究。共纳入并分析了23项研究，包括6494例病例和9884例对照。总体而言，在所有遗传模型下，均观察到该多态性与癌症风险之间存在显著关联。根据种族和癌症类型进行的亚组分析也检测到显著关联。NFKB1 -94插入/缺失多态性与亚洲人群的癌症风险相关（显性模型：OR=1.52，95%CI=1.17-1.98；隐性模型：OR=1.50，95%CI=1.26-1.79；II与DD比较：OR=1.90，95%CI=1.37-2.65；ID与DD比较：OR=1.32，95%CI=1.05-1.66；I与D比较：OR=1.37，95%CI=1.17-1.60），但在白种人群中无此关联。此外，在卵巢癌、肝癌和口腔鳞状细胞癌中观察到显著关联，但在乳腺癌和肺癌中未发现显著关联。当前的荟萃分析表明，NFKB1 -94插入/缺失多态性可能影响亚洲人群的癌症风险。
