Nian Xuewu, Zhang Wei, Li Limin, Sun Yan, Sun Erlin, Han Ruifa
Department of Urology, Tianjin Institute of Urology, National Key Clinical Specialty of Urology, Tianjin Key Lab of Urology, The Second Hospital of Tianjin Medical University, 23 Pingjiang Road, Hexi District, Tianjin, 300211, China.
Tumour Biol. 2014 Dec;35(12):11921-31. doi: 10.1007/s13277-014-2470-3. Epub 2014 Sep 5.
Nuclear factor-kappa B (NF-κB), a cell survival signal, is involved in carcinogenesis. Polymorphism of NF-κB1 is associated with cancer by several studies. This study aims to perform a comprehensive meta-analysis of studies and determine the association between the NF-κB1-94ins/del ATTG promoter polymorphism and cancer. Twenty-five case-control studies (7,281 cases and 10,039 controls) were included. We used odds ratios (ORs) to assess the strength of the association, and 95 % confidence intervals (CIs) to identify precision of the estimate. Overall, NF-κB1-94ins/del ATTG promoter polymorphism was significantly associated with decreased susceptibility to cancer in overall population under homozygote (for DD vs. WW: OR = 0.74, 95 % CI = 0.58-0.96), recessive (for DD vs. WD+WW: OR = 0.82, 95 % CI = 0.69-0.99), dominant (for DD+WD vs. WW: OR = 0.84, 95 % CI = 0.71-1.00), and allele (for D vs. W: OR = 0.88, 95 % CI = 0.78-0.98) model. Subgroup analysis for ethnicity found that NF-κB1-94ins/del ATTG promoter polymorphism was significantly associated with decreased susceptibility to cancer in Asians (for DD vs. WW: OR = 0.54, 95 % CI = 0.40-0.74; for WD vs. WW: OR = 0.75, 95 % CI = 0.69-0.81; for DD vs. WD+WW: OR = 0.70, 95 % CI = 0.55-0.90; for DD+WD vs. WW; OR = 0.66, 95 % CI = 0.56-0.78; for D vs. W: OR = 0.75, 95 % CI = 0.65-0.86), but the association was not found in Caucasians. The findings suggest that NF-κB1-94ins/delATTG promoter polymorphism is significantly associated with decreased susceptibility to cancer in overall and Asian population.
核因子-κB（NF-κB）是一种细胞存活信号，参与致癌过程。多项研究表明，NF-κB1的多态性与癌症有关。本研究旨在对相关研究进行全面的荟萃分析，以确定NF-κB1-94ins/del ATTG启动子多态性与癌症之间的关联。纳入了25项病例对照研究（7281例病例和10039例对照）。我们使用比值比（OR）评估关联强度，用95%置信区间（CI）确定估计的精确度。总体而言，在纯合子（DD与WW相比：OR = 0.74，95% CI = 0.58 - 0.96）、隐性（DD与WD + WW相比：OR = 0.82，95% CI = 0.69 - 0.99）、显性（DD + WD与WW相比：OR = 0.84，95% CI = 0.71 - 1.00）和等位基因（D与W相比：OR = 0.88，95% CI = 0.78 - 0.98）模型下，NF-κB1-94ins/del ATTG启动子多态性与总体人群中癌症易感性降低显著相关。按种族进行的亚组分析发现，NF-κB1-94ins/del ATTG启动子多态性与亚洲人群中癌症易感性降低显著相关（DD与WW相比：OR = 0.54，95% CI = 0.40 - 0.74；WD与WW相比：OR = 0.75, 95% CI = 0.69 - 0.81；DD与WD + WW相比：OR = 0.70，95% CI = 0.55 - 0.90；DD + WD与WW相比：OR = 0.66，95% CI = 0.56 - 0.78；D与W相比：OR = 0.75，95% CI = 0.65 - 0.86），但在白种人中未发现这种关联。研究结果表明，NF-κB1-94ins/del ATTG启动子多态性与总体人群及亚洲人群中癌症易感性降低显著相关。
