ZDOCK 服务器：蛋白质-蛋白质复合物和对称多聚体的交互式对接预测。
ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers.
机构信息
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 and Bioinformatics Program, Boston University, 44 Cummington Mall, Boston, MA 02215 USAProgram in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 and Bioinformatics Program, Boston University, 44 Cummington Mall, Boston, MA 02215 USA.
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605 and Bioinformatics Program, Boston University, 44 Cummington Mall, Boston, MA 02215 USA.
出版信息
Bioinformatics. 2014 Jun 15;30(12):1771-3. doi: 10.1093/bioinformatics/btu097. Epub 2014 Feb 14.
SUMMARY
Protein-protein interactions are essential to cellular and immune function, and in many cases, because of the absence of an experimentally determined structure of the complex, these interactions must be modeled to obtain an understanding of their molecular basis. We present a user-friendly protein docking server, based on the rigid-body docking programs ZDOCK and M-ZDOCK, to predict structures of protein-protein complexes and symmetric multimers. With a goal of providing an accessible and intuitive interface, we provide options for users to guide the scoring and the selection of output models, in addition to dynamic visualization of input structures and output docking models. This server enables the research community to easily and quickly produce structural models of protein-protein complexes and symmetric multimers for their own analysis.
AVAILABILITY
The ZDOCK server is freely available to all academic and non-profit users at: http://zdock.umassmed.edu. No registration is required.
摘要
蛋白质-蛋白质相互作用对于细胞和免疫功能至关重要，在许多情况下，由于缺乏复合物的实验确定结构，因此必须对这些相互作用进行建模，以了解其分子基础。我们提出了一个基于刚体对接程序 ZDOCK 和 M-ZDOCK 的用户友好型蛋白质对接服务器，用于预测蛋白质-蛋白质复合物和对称多聚体的结构。为了提供一个易于访问和直观的界面，我们为用户提供了选项，以指导评分和选择输出模型，此外还可以动态可视化输入结构和输出对接模型。该服务器使研究界能够轻松、快速地为自己的分析生成蛋白质-蛋白质复合物和对称多聚体的结构模型。
可及性
ZDOCK 服务器可供所有学术和非营利用户免费使用，网址为：http://zdock.umassmed.edu。无需注册。
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