吸入沙丁胺醇中毒所致代谢性酸中毒：一种使疑似急性重症哮喘病例管理复杂化的有害副作用。
Metabolic acidosis due to inhaled salbutamol toxicity: A hazardous side effect complicating management of suspected cases of acute severe asthma.
作者信息
Tomar R P S, Vasudevan R
机构信息
Classified Specialist, Dept of Paediatrics & Neonatology, MH Jalandhar Cant, Punjab 144005, India.
Senior Advisor, Dept of Paediatrics & Neonatology, MH Jalandhar Cant, Punjab 144005, India.
出版信息
Med J Armed Forces India. 2012 Jul;68(3):242-4. doi: 10.1016/j.mjafi.2011.10.002. Epub 2012 May 10.
Abstract
Metabolic acidosis has seldom been reported during treatment of asthma with use of beta agonist but not with much clinical consequence. We report two cases of metabolic acidosis with hyperventilation as a direct effect of salbutamol that caused difficulty in assessment and management of their respiratory symptoms which resolved with appropriate tapering of beta agonist.
摘要
在使用β受体激动剂治疗哮喘期间，很少有代谢性酸中毒的报道，且临床后果并不严重。我们报告了两例因沙丁胺醇直接作用导致通气过度引起的代谢性酸中毒病例，这给评估和处理其呼吸道症状带来了困难，通过适当减少β受体激动剂用量后症状得以缓解。
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本文引用的文献
1
Asthma in childhood.儿童哮喘
Pediatr Clin North Am. 2009 Feb;56(1):191-226, xii. doi: 10.1016/j.pcl.2008.10.008.
2
Metabolic acidosis, respiratory distress, and children with severe acute asthma.
Pediatr Crit Care Med. 2009 Jan;10(1):142-3; author reply 143. doi: 10.1097/PCC.0b013e3181937cc9.
3
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Pediatr Crit Care Med. 2007 Nov;8(6):519-23. doi: 10.1097/01.PCC.0000288673.82916.9D.
4
Pharmacogenomics of beta2-agonist: key focus on signaling pathways.β2 激动剂的药物基因组学：重点关注信号通路。
Pharmacogenomics. 2006 Sep;7(6):919-33. doi: 10.2217/14622416.7.6.919.
5
Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma.急性重症哮喘患者高剂量吸入沙丁胺醇治疗与血浆乳酸水平升高相关。
Emerg Med J. 2005 Jun;22(6):404-8. doi: 10.1136/emj.2003.012039.
6
Diabetic ketoacidosis associated with oral salbutamol overdose.
Am J Med. 2002 Dec 1;113(8):701-2. doi: 10.1016/s0002-9343(02)01294-9.
7
Lactic acidosis and status asthmaticus: how common in pediatrics?乳酸酸中毒与哮喘持续状态：在儿科中常见吗？
Ann Allergy Asthma Immunol. 2002 Dec;89(6):585-8. doi: 10.1016/S1081-1206(10)62106-0.
8
Lactic acidosis in asthma: report of two cases and review of the literature.哮喘中的乳酸酸中毒：两例报告及文献综述
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Am J Obstet Gynecol. 1981 Nov 15;141(6):617-24. doi: 10.1016/s0002-9378(15)33300-7.
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