Suzuki S S, Smith G K
Department of Psychology, McMaster University, Hamilton, Ont., Canada.
Electroencephalogr Clin Neurophysiol. 1988 Jun;69(6):532-40. doi: 10.1016/0013-4694(88)90165-4.
Spontaneous EEG spikes (SPKs) were recorded from the CA1 region of the dorsal hippocampus in normal rats during awake immobility and slow wave sleep. These SPKs were accompanied by synchronous burst discharges in the pyramidal cell layer. These discharges are called 'population bursts (PBs)' in that they seem to require a population of synchronously bursting neurons. PBs were classified into 2 forms on the basis of their morphologies. One form (mixed burst or MB) consisted of a mixture or superimposition of action potential bursts from a relatively small number of neurons. The other form (ripple) was a series of 3-13 (typically 5-8) high frequency (125-250 Hz) waves, usually waxing and waning. Unit action potentials were superimposed mainly on negative portions of these high frequency waves. The ripple was considered to represent summed activity of highly synchronized complex spike bursts from a relatively large number of pyramidal cells. The similarity in wave structure between these non-pathological ripples and multipeaked, epileptiform (interictal) field potentials recorded from the penicillin-treated hippocampus suggests that they may share some common underlying mechanisms.
在正常大鼠清醒不动和慢波睡眠期间，从背侧海马体的CA1区域记录到自发脑电图尖峰（SPKs）。这些SPKs伴随着锥体细胞层的同步爆发性放电。这些放电被称为“群体爆发（PBs）”，因为它们似乎需要一群同步爆发的神经元。根据PBs的形态，将其分为两种形式。一种形式（混合爆发或MB）由相对少量神经元的动作电位爆发的混合或叠加组成。另一种形式（涟漪）是一系列3 - 13个（通常为5 - 8个）高频（125 - 250赫兹）波，通常呈逐渐增强和减弱的趋势。单位动作电位主要叠加在这些高频波的负相部分。涟漪被认为代表了来自相对大量锥体细胞的高度同步复合尖峰爆发的总和活动。这些非病理性涟漪与从青霉素处理的海马体记录到的多峰、癫痫样（发作间期）场电位之间的波结构相似性表明，它们可能共享一些共同的潜在机制。
