癫痫大脑中高频振荡（80 - 800赫兹）的谜题。
Conundrums of high-frequency oscillations (80-800 Hz) in the epileptic brain.
作者信息
Menendez de la Prida Liset, Staba Richard J, Dian Joshua A
机构信息
*Department of Functional and Systems Neuroscience, Instituto Cajal, CSIC, Madrid, Spain; †Departmentof Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, U.S.A.; and ‡Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.
出版信息
J Clin Neurophysiol. 2015 Jun;32(3):207-19. doi: 10.1097/WNP.0000000000000150.
Pathological high-frequency oscillations (HFOs) (80-800 Hz) are considered biomarkers of epileptogenic tissue, but the underlying complex neuronal events are not well understood. Here, we identify and discuss several outstanding issues or conundrums in regards to the recording, analysis, and interpretation of HFOs in the epileptic brain to critically highlight what is known and what is not about these enigmatic events. High-frequency oscillations reflect a range of neuronal processes contributing to overlapping frequencies from the lower 80 Hz to the very fast spectral frequency bands. Given their complex neuronal nature, HFOs are extremely sensitive to recording conditions and analytical approaches. We provide a list of recommendations that could help to obtain comparable HFO signals in clinical and basic epilepsy research. Adopting basic standards will facilitate data sharing and interpretation that collectively will aid in understanding the role of HFOs in health and disease for translational purpose.
病理性高频振荡（HFOs）（80 - 800赫兹）被认为是致痫组织的生物标志物，但潜在的复杂神经元事件尚未得到充分理解。在此，我们识别并讨论了关于癫痫性大脑中HFOs的记录、分析和解释方面的几个突出问题或谜题，以批判性地突出关于这些神秘事件已知和未知的内容。高频振荡反映了一系列神经元过程，这些过程导致从较低的80赫兹到非常快的频谱频段的频率重叠。鉴于其复杂的神经元性质，HFOs对记录条件和分析方法极其敏感。我们提供了一系列建议，这些建议有助于在临床和基础癫痫研究中获得可比较的HFO信号。采用基本标准将促进数据共享和解释，这将共同有助于理解HFOs在健康和疾病中的作用，以实现转化目的。
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