Zambrano Marina B, Brizola Evelise S, Refosco Lilia, Giugliani Roberto, Félix Têmis M
a PostGraduate Program in Child and Adolescent Health, Federal University of Rio Grande do Sul , Porto Alegre , BRAZIL.
J Am Coll Nutr. 2014;33(1):18-25. doi: 10.1080/07315724.2013.827065.
The aim of the present study was to assess anthropometric measurements, nutritional status, dietary intake, and body fat percentage of pediatric patients with osteogenesis imperfecta (OI).
A cross-sectional study evaluated 63 OI patients from 0 to 19 years of age. We analyzed anthropometric measurements, mobility, bisphosphonate treatment, body fat percentage (by dual-energy x-ray absorptiometry [DEXA] and sum of skinfold thickness), nutritional status, and dietary intake (using World Health Organization [WHO] and dietary reference intake recommendations for macronutrients and calcium intake, respectively). Participants' energy requirements were calculated using both kilocalorie per centimeter measurements and WHO methods.
Patients with different types of OI had different anthropometric measurements (p < 0.05), where OI type III had severely limited stature and poor mobility. Nutritional status was correlated with measurements of arm circumference and body fat. We also found a strong correlation between the 2 methods used to calculate percentage of body fat (r = 0.803). OI type III had a higher percentage of energy intake. We observed that 75% of subjects had a calcium intake below 95% of recommended daily value and there was an inverse correlation between age and calcium intake.
This study showed that stature was compromised mainly in OI type III. Skinfold thickness and arm circumference correlated to nutritional status and also to body fat calculated by DEXA. Daily calcium intake was below the recommended levels in pediatric patients with OI. These findings are important for the management of OI subjects.
本研究旨在评估成骨不全症（OI）患儿的人体测量指标、营养状况、饮食摄入量和体脂百分比。
一项横断面研究评估了63名0至19岁的OI患者。我们分析了人体测量指标、活动能力、双膦酸盐治疗、体脂百分比（通过双能X线吸收法[DEXA]和皮褶厚度总和）、营养状况和饮食摄入量（分别使用世界卫生组织[WHO]和宏量营养素及钙摄入量的膳食参考摄入量建议）。参与者的能量需求使用每厘米千卡测量法和WHO方法进行计算。
不同类型OI的患者有不同的人体测量指标（p<0.05），其中III型OI患者身高严重受限且活动能力差。营养状况与上臂围和体脂测量值相关。我们还发现用于计算体脂百分比的两种方法之间存在很强的相关性（r=0.803）。III型OI患者的能量摄入量百分比更高。我们观察到75%的受试者钙摄入量低于推荐每日值的95%，且年龄与钙摄入量呈负相关。
本研究表明，身高受损主要发生在III型OI患者中。皮褶厚度和上臂围与营养状况以及通过DEXA计算的体脂相关。OI患儿的每日钙摄入量低于推荐水平。这些发现对OI患者的管理很重要。
